The effect of prophylactic antipyretic administration on post-vaccination adverse reactions and antibody response in children: a systematic review
Prophylactic antipyretic administration decreases the post-vaccination adverse reactions. Recent study finds that they may also decrease the antibody responses to several vaccine antigens. This systematic review aimed to assess the evidence for a relationship between prophylactic antipyretic adminis...
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| description | Prophylactic antipyretic administration decreases the post-vaccination adverse reactions. Recent study finds that they may also decrease the antibody responses to several vaccine antigens. This systematic review aimed to assess the evidence for a relationship between prophylactic antipyretic administration, post-vaccination adverse events, and antibody response in children.
A systematic search of major databases including MEDLINE and EMBASE was carried out till March 2014. Randomized controlled trials (RCTs) comparing prophylactic antipyretic treatment versus placebo post-vaccination in children ≤ 6 years of age were included. Two reviewers independently applied eligibility criteria, assessed the studies for methodological quality, and extracted data [PROSPERO registration: CRD42014009717].
Of 2579 citations retrieved, a total of 13 RCTs including 5077 children were included in the review. Prophylactic antipyretic administration significantly reduced the febrile reactions (≥ 38.0 °C) after primary and booster vaccinations. Though there were statistically significant differences in the antibody responses between the two groups, the prophylactic PCM group had what would be considered protective levels of antibodies to all of the antigens given after the primary and booster vaccinations. No significant difference in the nasopharyngeal carriage rates (short-term and long-term) of H. influenzae or S. pneumoniae serotypes was found between the prophylactic and no prophylactic PCM group. There was a significant reduction in the local and systemic symptoms after primary, but not booster vaccinations.
Though prophylactic antipyretic administration leads to relief of the local and systemic symptoms after primary vaccinations, there is a reduction in antibody responses to some vaccine antigens without any effect on the nasopharyngeal carriage rates of S. pneumoniae & H. influenza serotypes. Future trials and surveillance programs should also aim at assessing the effectiveness of programs where prophylactic administration of PCM is given. The timing of administration of antipyretics should be discussed with the parents after explaining the benefits & risks. |
| doi_str_mv | 10.1371/journal.pone.0106629 |
| format | Article |
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A systematic search of major databases including MEDLINE and EMBASE was carried out till March 2014. Randomized controlled trials (RCTs) comparing prophylactic antipyretic treatment versus placebo post-vaccination in children ≤ 6 years of age were included. Two reviewers independently applied eligibility criteria, assessed the studies for methodological quality, and extracted data [PROSPERO registration: CRD42014009717].
Of 2579 citations retrieved, a total of 13 RCTs including 5077 children were included in the review. Prophylactic antipyretic administration significantly reduced the febrile reactions (≥ 38.0 °C) after primary and booster vaccinations. Though there were statistically significant differences in the antibody responses between the two groups, the prophylactic PCM group had what would be considered protective levels of antibodies to all of the antigens given after the primary and booster vaccinations. No significant difference in the nasopharyngeal carriage rates (short-term and long-term) of H. influenzae or S. pneumoniae serotypes was found between the prophylactic and no prophylactic PCM group. There was a significant reduction in the local and systemic symptoms after primary, but not booster vaccinations.
Though prophylactic antipyretic administration leads to relief of the local and systemic symptoms after primary vaccinations, there is a reduction in antibody responses to some vaccine antigens without any effect on the nasopharyngeal carriage rates of S. pneumoniae & H. influenza serotypes. Future trials and surveillance programs should also aim at assessing the effectiveness of programs where prophylactic administration of PCM is given. The timing of administration of antipyretics should be discussed with the parents after explaining the benefits & risks.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0106629</identifier><identifier>PMID: 25180516</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analgesics ; Antibodies ; Antibodies - immunology ; Antibody response ; Antigen-antibody reactions ; Antigens ; Antipyretics - pharmacology ; Biology and Life Sciences ; Child ; Children ; Children & youth ; Clinical trials ; Collaboration ; Complications and side effects ; Diphtheria ; Haemophilus influenzae ; Handbooks ; Hepatitis ; Humans ; Influenza ; Medicine and Health Sciences ; Nonsteroidal anti-inflammatory drugs ; Pain ; Parents ; Pediatrics ; Pneumonia ; Poliomyelitis ; Reduction ; Reviews ; Serotypes ; Side effects ; Statistical analysis ; Streptococcus infections ; Studies ; Systematic review ; Tetanus ; Treatment Outcome ; Vaccination ; Vaccination - adverse effects ; Vaccines ; Whooping cough</subject><ispartof>PloS one, 2014-09, Vol.9 (9), p.e106629</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Das et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Das et al 2014 Das et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c717t-73f610ca257de362b12bcbfd2d25ca8c501bfe5799fe71e1e67bbe24ffad61533</citedby><cites>FETCH-LOGICAL-c717t-73f610ca257de362b12bcbfd2d25ca8c501bfe5799fe71e1e67bbe24ffad61533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152293/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152293/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25180516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Quach, Caroline</contributor><creatorcontrib>Das, Rashmi Ranjan</creatorcontrib><creatorcontrib>Panigrahi, Inusha</creatorcontrib><creatorcontrib>Naik, Sushree Samiksha</creatorcontrib><title>The effect of prophylactic antipyretic administration on post-vaccination adverse reactions and antibody response in children: a systematic review</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Prophylactic antipyretic administration decreases the post-vaccination adverse reactions. Recent study finds that they may also decrease the antibody responses to several vaccine antigens. This systematic review aimed to assess the evidence for a relationship between prophylactic antipyretic administration, post-vaccination adverse events, and antibody response in children.
A systematic search of major databases including MEDLINE and EMBASE was carried out till March 2014. Randomized controlled trials (RCTs) comparing prophylactic antipyretic treatment versus placebo post-vaccination in children ≤ 6 years of age were included. Two reviewers independently applied eligibility criteria, assessed the studies for methodological quality, and extracted data [PROSPERO registration: CRD42014009717].
Of 2579 citations retrieved, a total of 13 RCTs including 5077 children were included in the review. Prophylactic antipyretic administration significantly reduced the febrile reactions (≥ 38.0 °C) after primary and booster vaccinations. Though there were statistically significant differences in the antibody responses between the two groups, the prophylactic PCM group had what would be considered protective levels of antibodies to all of the antigens given after the primary and booster vaccinations. No significant difference in the nasopharyngeal carriage rates (short-term and long-term) of H. influenzae or S. pneumoniae serotypes was found between the prophylactic and no prophylactic PCM group. There was a significant reduction in the local and systemic symptoms after primary, but not booster vaccinations.
Though prophylactic antipyretic administration leads to relief of the local and systemic symptoms after primary vaccinations, there is a reduction in antibody responses to some vaccine antigens without any effect on the nasopharyngeal carriage rates of S. pneumoniae & H. influenza serotypes. Future trials and surveillance programs should also aim at assessing the effectiveness of programs where prophylactic administration of PCM is given. The timing of administration of antipyretics should be discussed with the parents after explaining the benefits & risks.</description><subject>Analgesics</subject><subject>Antibodies</subject><subject>Antibodies - immunology</subject><subject>Antibody response</subject><subject>Antigen-antibody reactions</subject><subject>Antigens</subject><subject>Antipyretics - pharmacology</subject><subject>Biology and Life Sciences</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Clinical trials</subject><subject>Collaboration</subject><subject>Complications and side effects</subject><subject>Diphtheria</subject><subject>Haemophilus influenzae</subject><subject>Handbooks</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Influenza</subject><subject>Medicine and Health Sciences</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Pain</subject><subject>Parents</subject><subject>Pediatrics</subject><subject>Pneumonia</subject><subject>Poliomyelitis</subject><subject>Reduction</subject><subject>Reviews</subject><subject>Serotypes</subject><subject>Side effects</subject><subject>Statistical analysis</subject><subject>Streptococcus infections</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Tetanus</subject><subject>Treatment Outcome</subject><subject>Vaccination</subject><subject>Vaccination - 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Recent study finds that they may also decrease the antibody responses to several vaccine antigens. This systematic review aimed to assess the evidence for a relationship between prophylactic antipyretic administration, post-vaccination adverse events, and antibody response in children.
A systematic search of major databases including MEDLINE and EMBASE was carried out till March 2014. Randomized controlled trials (RCTs) comparing prophylactic antipyretic treatment versus placebo post-vaccination in children ≤ 6 years of age were included. Two reviewers independently applied eligibility criteria, assessed the studies for methodological quality, and extracted data [PROSPERO registration: CRD42014009717].
Of 2579 citations retrieved, a total of 13 RCTs including 5077 children were included in the review. Prophylactic antipyretic administration significantly reduced the febrile reactions (≥ 38.0 °C) after primary and booster vaccinations. Though there were statistically significant differences in the antibody responses between the two groups, the prophylactic PCM group had what would be considered protective levels of antibodies to all of the antigens given after the primary and booster vaccinations. No significant difference in the nasopharyngeal carriage rates (short-term and long-term) of H. influenzae or S. pneumoniae serotypes was found between the prophylactic and no prophylactic PCM group. There was a significant reduction in the local and systemic symptoms after primary, but not booster vaccinations.
Though prophylactic antipyretic administration leads to relief of the local and systemic symptoms after primary vaccinations, there is a reduction in antibody responses to some vaccine antigens without any effect on the nasopharyngeal carriage rates of S. pneumoniae & H. influenza serotypes. Future trials and surveillance programs should also aim at assessing the effectiveness of programs where prophylactic administration of PCM is given. The timing of administration of antipyretics should be discussed with the parents after explaining the benefits & risks.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25180516</pmid><doi>10.1371/journal.pone.0106629</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Analgesics Antibodies Antibodies - immunology Antibody response Antigen-antibody reactions Antigens Antipyretics - pharmacology Biology and Life Sciences Child Children Children & youth Clinical trials Collaboration Complications and side effects Diphtheria Haemophilus influenzae Handbooks Hepatitis Humans Influenza Medicine and Health Sciences Nonsteroidal anti-inflammatory drugs Pain Parents Pediatrics Pneumonia Poliomyelitis Reduction Reviews Serotypes Side effects Statistical analysis Streptococcus infections Studies Systematic review Tetanus Treatment Outcome Vaccination Vaccination - adverse effects Vaccines Whooping cough |
| title | The effect of prophylactic antipyretic administration on post-vaccination adverse reactions and antibody response in children: a systematic review |
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