Immunohistochemical analysis of the mechanistic target of rapamycin and hypoxia signalling pathways in basal cell carcinoma and trichoepithelioma

Basal cell carcinoma (BCC) is the most common cancer in Caucasians. Trichoepithelioma (TE) is a benign neoplasm that strongly resembles BCC. Both are hair follicle (HF) tumours. HFs are hypoxic microenvironments, therefore we hypothesized that hypoxia-induced signalling pathways could be involved in...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e106427-e106427
Hauptverfasser:	Brinkhuizen, Tjinta, Weijzen, Chantal A H, Eben, Jonathan, Thissen, Monique R, van Marion, Ariënne M, Lohman, Björn G, Winnepenninckx, Véronique J L, Nelemans, Patty J, van Steensel, Maurice A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Apoptosis Basal cell carcinoma Biology and Life Sciences BNIP3 protein Cancer Carcinoma Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - pathology Cell Hypoxia Dermatology Developmental biology Diagnostic software Diagnostic systems Female Formaldehyde Gene expression Genes Humans Hypoxia Hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Immunohistochemistry Kinases Male Medical prognosis Medicine and Health Sciences Melanoma Microenvironments Middle Aged Neoplastic Syndromes, Hereditary - metabolism Neoplastic Syndromes, Hereditary - pathology Oncology Paraffin Pathology Phosphorylation Proteins Rapamycin Signal transduction Signal Transduction - genetics Signaling Skin cancer Skin Neoplasms - metabolism Skin Neoplasms - pathology Staining and Labeling Statistics, Nonparametric TOR protein TOR Serine-Threonine Kinases - metabolism Transcription factors Trichoepithelioma Tumors Vascular endothelial growth factor
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