Simulated cytoskeletal collapse via tau degradation

We present a coarse-grained two dimensional mechanical model for the microtubule-tau bundles in neuronal axons in which we remove taus, as can happen in various neurodegenerative conditions such as Alzheimers disease, tauopathies, and chronic traumatic encephalopathy. Our simplified model includes (...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e104965-e104965
Hauptverfasser:	Sendek, Austin, Fuller, Henry R, Hayre, N Robert, Singh, Rajiv R P, Cox, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Alzheimers disease Axons Axons - chemistry Axons - ultrastructure Biochemistry Biology and Life Sciences Biomechanical Phenomena Bundles Bundling Chronic traumatic encephalopathy Collapse Compression Computer Simulation Cytoskeleton Depletion Dynamic instability Dynamic stability Encephalopathy Humans In vitro methods and tests Instability Medicine and Health Sciences Microtubules Microtubules - chemistry Microtubules - ultrastructure Models, Biological Neurodegenerative diseases Percolation Percolation theory Phosphorylation Physical Sciences Physics Proteins Rigidity Tau protein tau Proteins - chemistry Tauopathies - pathology Thermodynamics Tips Two dimensional models
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