Cortico-cortical interactions influence binocularity of the primary visual cortex of adult mice
Electrophysiological studies have revealed that a large proportion of the mouse primary visual cortex (V1) receives input also from the ipsilateral eye. This is surprising as most optic nerve fibers cross at the optic chiasm in mice. Inactivating V1 of one hemisphere has recently demonstrated a stro...
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| description | Electrophysiological studies have revealed that a large proportion of the mouse primary visual cortex (V1) receives input also from the ipsilateral eye. This is surprising as most optic nerve fibers cross at the optic chiasm in mice. Inactivating V1 of one hemisphere has recently demonstrated a strong contribution of one hemisphere's activity on binocularity of single units and visually evoked potentials of V1 in the other hemisphere of young rats and of single units in young adult mice. Here we used intrinsic signal optical imaging to quantitatively study the influence of cortico-cortical connections on the magnitude of neuronal activation in the entire binocular zone of adult mouse V1. We simultaneously measured V1-activity of both hemispheres in adult C57BL/6J mice before and after blocking sensory-driven activity in one hemisphere with muscimol. In V1 contralateral to the inactivation, ipsilateral eye evoked activity was reduced by on average 18% while contralateral eye evoked activity did not change. Our results clearly show that cortico-cortical interactions exert a global amplification of ipsilateral eye evoked activity in adult mouse V1. |
| doi_str_mv | 10.1371/journal.pone.0105745 |
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This is surprising as most optic nerve fibers cross at the optic chiasm in mice. Inactivating V1 of one hemisphere has recently demonstrated a strong contribution of one hemisphere's activity on binocularity of single units and visually evoked potentials of V1 in the other hemisphere of young rats and of single units in young adult mice. Here we used intrinsic signal optical imaging to quantitatively study the influence of cortico-cortical connections on the magnitude of neuronal activation in the entire binocular zone of adult mouse V1. We simultaneously measured V1-activity of both hemispheres in adult C57BL/6J mice before and after blocking sensory-driven activity in one hemisphere with muscimol. In V1 contralateral to the inactivation, ipsilateral eye evoked activity was reduced by on average 18% while contralateral eye evoked activity did not change. Our results clearly show that cortico-cortical interactions exert a global amplification of ipsilateral eye evoked activity in adult mouse V1.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0105745</identifier><identifier>PMID: 25157503</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Binocular vision ; Biology and Life Sciences ; Brain research ; Cameras ; Collaboration ; Cortex (somatosensory) ; Deactivation ; Evoked Potentials, Visual ; Eye ; Female ; Hemispheres ; Inactivation ; Mice ; Mice, Inbred C57BL ; Muscimol ; Neuroimaging ; Neurosciences ; Optic chiasm ; Optic nerve ; Optical communication ; Optical fibers ; Optics ; Photic Stimulation ; Rats ; Signal processing ; Vision, Binocular ; Visual cortex ; Visual Cortex - physiology ; Visual Pathways</subject><ispartof>PloS one, 2014-08, Vol.9 (8), p.e105745-e105745</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Dehmel, Löwel. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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This is surprising as most optic nerve fibers cross at the optic chiasm in mice. Inactivating V1 of one hemisphere has recently demonstrated a strong contribution of one hemisphere's activity on binocularity of single units and visually evoked potentials of V1 in the other hemisphere of young rats and of single units in young adult mice. Here we used intrinsic signal optical imaging to quantitatively study the influence of cortico-cortical connections on the magnitude of neuronal activation in the entire binocular zone of adult mouse V1. We simultaneously measured V1-activity of both hemispheres in adult C57BL/6J mice before and after blocking sensory-driven activity in one hemisphere with muscimol. In V1 contralateral to the inactivation, ipsilateral eye evoked activity was reduced by on average 18% while contralateral eye evoked activity did not change. Our results clearly show that cortico-cortical interactions exert a global amplification of ipsilateral eye evoked activity in adult mouse V1.</description><subject>Animals</subject><subject>Binocular vision</subject><subject>Biology and Life Sciences</subject><subject>Brain research</subject><subject>Cameras</subject><subject>Collaboration</subject><subject>Cortex (somatosensory)</subject><subject>Deactivation</subject><subject>Evoked Potentials, Visual</subject><subject>Eye</subject><subject>Female</subject><subject>Hemispheres</subject><subject>Inactivation</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Muscimol</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Optic chiasm</subject><subject>Optic nerve</subject><subject>Optical communication</subject><subject>Optical fibers</subject><subject>Optics</subject><subject>Photic Stimulation</subject><subject>Rats</subject><subject>Signal processing</subject><subject>Vision, Binocular</subject><subject>Visual cortex</subject><subject>Visual Cortex - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dehmel, Susanne</au><au>Löwel, Siegrid</au><au>Vyazovskiy, Vladyslav</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortico-cortical interactions influence binocularity of the primary visual cortex of adult mice</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-08-26</date><risdate>2014</risdate><volume>9</volume><issue>8</issue><spage>e105745</spage><epage>e105745</epage><pages>e105745-e105745</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Electrophysiological studies have revealed that a large proportion of the mouse primary visual cortex (V1) receives input also from the ipsilateral eye. This is surprising as most optic nerve fibers cross at the optic chiasm in mice. Inactivating V1 of one hemisphere has recently demonstrated a strong contribution of one hemisphere's activity on binocularity of single units and visually evoked potentials of V1 in the other hemisphere of young rats and of single units in young adult mice. Here we used intrinsic signal optical imaging to quantitatively study the influence of cortico-cortical connections on the magnitude of neuronal activation in the entire binocular zone of adult mouse V1. We simultaneously measured V1-activity of both hemispheres in adult C57BL/6J mice before and after blocking sensory-driven activity in one hemisphere with muscimol. In V1 contralateral to the inactivation, ipsilateral eye evoked activity was reduced by on average 18% while contralateral eye evoked activity did not change. Our results clearly show that cortico-cortical interactions exert a global amplification of ipsilateral eye evoked activity in adult mouse V1.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25157503</pmid><doi>10.1371/journal.pone.0105745</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Binocular vision Biology and Life Sciences Brain research Cameras Collaboration Cortex (somatosensory) Deactivation Evoked Potentials, Visual Eye Female Hemispheres Inactivation Mice Mice, Inbred C57BL Muscimol Neuroimaging Neurosciences Optic chiasm Optic nerve Optical communication Optical fibers Optics Photic Stimulation Rats Signal processing Vision, Binocular Visual cortex Visual Cortex - physiology Visual Pathways |
| title | Cortico-cortical interactions influence binocularity of the primary visual cortex of adult mice |
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