A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression

Degeneration of basal forebrain cholinergic neurons contributes significantly to the cognitive deficits associated with Alzheimer's disease (AD) and has been attributed to aberrant signaling through the neurotrophin receptor p75 (p75NTR). Thus, modulating p75NTR signaling is considered a promis...

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Veröffentlicht in:	PloS one 2014, Vol.9 (8), p.e102136
Hauptverfasser:	Simmons, Danielle A, Knowles, Juliet K, Belichenko, Nadia P, Banerjee, Gargi, Finkle, Carly, Massa, Stephen M, Longo, Frank M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - pathology Alzheimer's disease Amyloid Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animal cognition Animal models Animals Atrophy Axons Basal forebrain Brain Cholinergic Neurons - drug effects Cognitive ability Cortex Degeneration Disease Models, Animal Disease Progression Drug dosages Drug Evaluation, Preclinical Dystrophy Female Forebrain Forebrain (basal) Gene expression Growth factors Humans Isoleucine - analogs & derivatives Isoleucine - pharmacology Kinases Laboratory animals Ligands Male Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Transgenic Morpholines - pharmacology Mutation Nerve Degeneration - prevention & control Neural networks Neurites Neurodegenerative diseases Neurology Neurons Pathology Protective Agents - pharmacology Proteins Quantitative analysis Receptor, Nerve Growth Factor - metabolism Rodents Signal Transduction Signaling Therapeutic applications
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