Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease

Filamentous inclusions of the microtubule-associated protein, tau, define a variety of neurodegenerative diseases known as tauopathies, including Alzheimer's disease (AD). To better understand the role of tau-mediated effects on pathophysiology and global central nervous system function, we ext...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e106050-e106050
Hauptverfasser:	Wes, Paul D, Easton, Amy, Corradi, John, Barten, Donna M, Devidze, Nino, DeCarr, Lynn B, Truong, Amy, He, Aiqing, Barrezueta, Nestor X, Polson, Craig, Bourin, Clotilde, Flynn, Marianne E, Keenan, Stefanie, Lidge, Regina, Meredith, Jere, Natale, Joanne, Sankaranarayanan, Sethu, Cadelina, Greg W, Albright, Charlie F, Cacace, Angela M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer's disease Animals Basal ganglia Biology and Life Sciences Central nervous system Central nervous system diseases Chief executive officers Chromosome 17 Chromosomes, Human, Pair 17 - genetics Dementia disorders Disease Models, Animal Female Frontotemporal dementia Frontotemporal Dementia - genetics Gene expression Gene Expression - genetics Gene regulation Gene Regulatory Networks - genetics Generic drugs Hippocampus - metabolism Humans Immune response Inflammation Inflammation - genetics Kinases Medicine and Health Sciences Mice Microglia - metabolism Microtubule-Associated Proteins - genetics Movement disorders Neurodegenerative diseases Neurodegenerative Diseases - genetics Neurological diseases Neurons - metabolism Neurosciences Parkinsonian Disorders - genetics Pathogenesis Research and Analysis Methods Rodents Tau protein tau Proteins - genetics β-Amyloid
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