The N-reductive system composed of mitochondrial amidoxime reducing component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase (CYB5R) is regulated by fasting and high fat diet in mice

The mitochondrial amidoxime reducing component mARC is the fourth mammalian molybdenum enzyme. The protein is capable of reducing N-oxygenated structures, but requires cytochrome b5 and cytochrome b5 reductase for electron transfer to catalyze such reactions. It is well accepted that the enzyme is i...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e105371-e105371
Hauptverfasser:	Jakobs, Heyka H, Mikula, Michal, Havemeyer, Antje, Strzalkowska, Adriana, Borowa-Chmielak, Monika, Dzwonek, Artur, Gajewska, Marta, Hennig, Ewa E, Ostrowski, Jerzy, Clement, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animal models Animals Benzamidine Benzamidines - metabolism Biology and Life Sciences Biotransformation Cancer Cell culture Cell Line, Tumor Chemical compounds Chemical reactions Cytochrome Cytochrome b5 Cytochrome-B Reductase - metabolism Cytochromes b5 - metabolism Diabetes Diet Diet, High-Fat Drug metabolism Drugs Electron transfer Energy metabolism Enzyme Activation Enzymes Fasting Gastroenterology Gene expression Genomes Hepatology High fat diet Humans Hyperphagia - metabolism In vivo methods and tests Laboratory animals Lipid Metabolism Lipids Lipogenesis Male Medicine and Health Sciences Metabolic syndrome Metabolism Metabolites Mice Mitochondria Mitochondrial Proteins - metabolism Molybdenum Oncology Oxidoreductases - metabolism Pharmaceutical sciences Prodrugs Protein expression Protein turnover Proteins Reductase Rodents
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