The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration

The MacBlue transgenic mouse uses the Csf1r promoter and first intron to drive expression of gal4-VP16, which in turn drives a cointegrated gal4-responsive UAS-ECFP cassette. The Csf1r promoter region used contains a deletion of a 150 bp conserved region covering trophoblast and osteoclast-specific...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e105429-e105429
Hauptverfasser:	Sauter, Kristin A, Pridans, Clare, Sehgal, Anuj, Bain, Calum C, Scott, Charlotte, Moffat, Lindsey, Rojo, Rocío, Stutchfield, Ben M, Davies, Claire L, Donaldson, David S, Renault, Kathleen, McColl, Barry W, Mowat, Alan M, Serrels, Alan, Frame, Margaret C, Mabbott, Neil A, Hume, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Animals Biocompatibility Biology and Life Sciences Biomarkers - metabolism Biomedical materials Blood Cell differentiation Cell Differentiation - genetics Clonal deletion Dendritic cells Dendritic structure Differentiation (biology) Digestive system Digestive tract Embryonic development Embryos Female Follicles Gastrointestinal tract Gene deletion Genetic engineering Green Fluorescent Proteins - genetics Hepatocytes Immunohistochemistry Infections Infiltration Inflammation Intestinal Mucosa - metabolism Kidney - metabolism Kidneys Kinases Kupffer cells Kupffer Cells - metabolism Laboratories Lamina propria Langerhans cells Langerhans Cells - drug effects Langerhans Cells - metabolism Liver Liver - metabolism Lungs Lymphocytes Macrophage Colony-Stimulating Factor - metabolism Macrophages Male Medical research Mice Mice, Transgenic - genetics Microglia Microglia - metabolism Monocytes Monocytes - metabolism Myeloid cells Peripheral blood Peyer's patches Peyer's Patches - metabolism Protection and preservation Proteins Receptor, Macrophage Colony-Stimulating Factor - genetics Spleen Spleen - metabolism Stem cells Trans-Activators - genetics Transcription Transgenes Transgenes - genetics Transgenic mice VP16 protein Yolk Yolk sac Yolk Sac - metabolism
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