Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variability
Exposure to particulate matter (PM) has been associated with an increase in many inflammatory markers, including interleukin 6 (IL6). Air pollution exposure has also been suggested to induce an imbalance in the autonomic nervous system (ANS), such as a decrease in heart rate variability (HRV). In th...
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| creator | Adam, Martin Imboden, Medea Boes, Eva Schaffner, Emmanuel Künzli, Nino Phuleria, Harish Chandra Kronenberg, Florian Gaspoz, Jean-Michel Carballo, David Probst-Hensch, Nicole |
| description | Exposure to particulate matter (PM) has been associated with an increase in many inflammatory markers, including interleukin 6 (IL6). Air pollution exposure has also been suggested to induce an imbalance in the autonomic nervous system (ANS), such as a decrease in heart rate variability (HRV). In this study we aimed to investigate the modifying effect of polymorphisms in a major proinflammatory marker gene, interleukin 6 (IL6), on the relationship between long-term exposure to traffic-related PM10 (TPM10) and HRV.
For this cross-sectional study we analysed 1552 participants of the SAPALDIA cohort aged 50 years and older. Included were persons with valid genotype data, who underwent ambulatory 24-hr electrocardiogram monitoring, and reported on medical history and lifestyle. Main effects of annual average TPM10 and IL6 gene variants (rs1800795; rs2069827; rs2069840; rs10242595) on HRV indices and their interaction with average annual exposure to TPM10 were tested, applying a multivariable mixed linear model.
No overall association of TPM10 on HRV was found. Carriers of two proinflammatory G-alleles of the functional IL6 -174 G/C (rs1800795) polymorphism exhibited lower HRV. An inverse association between a 1 µg/m3 increment in yearly averaged TPM10 and HRV was restricted to GG genotypes at this locus with a standard deviation of normal-to-normal intervals (SDNN) (GG-carriers: -1.8%; 95% confidence interval -3.5 to 0.01; pinteraction(additive) = 0.028); and low frequency power (LF) (GG-carriers: -5.7%; 95%CI: -10.4 to -0.8; pinteraction(dominant) = 0.049).
Our results are consistent with the hypothesis that traffic-related air pollution decreases heart rate variability through inflammatory mechanisms. |
| doi_str_mv | 10.1371/journal.pone.0104978 |
| format | Article |
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For this cross-sectional study we analysed 1552 participants of the SAPALDIA cohort aged 50 years and older. Included were persons with valid genotype data, who underwent ambulatory 24-hr electrocardiogram monitoring, and reported on medical history and lifestyle. Main effects of annual average TPM10 and IL6 gene variants (rs1800795; rs2069827; rs2069840; rs10242595) on HRV indices and their interaction with average annual exposure to TPM10 were tested, applying a multivariable mixed linear model.
No overall association of TPM10 on HRV was found. Carriers of two proinflammatory G-alleles of the functional IL6 -174 G/C (rs1800795) polymorphism exhibited lower HRV. An inverse association between a 1 µg/m3 increment in yearly averaged TPM10 and HRV was restricted to GG genotypes at this locus with a standard deviation of normal-to-normal intervals (SDNN) (GG-carriers: -1.8%; 95% confidence interval -3.5 to 0.01; pinteraction(additive) = 0.028); and low frequency power (LF) (GG-carriers: -5.7%; 95%CI: -10.4 to -0.8; pinteraction(dominant) = 0.049).
Our results are consistent with the hypothesis that traffic-related air pollution decreases heart rate variability through inflammatory mechanisms.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0104978</identifier><identifier>PMID: 25133672</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Air pollution ; Analysis ; Atherosclerosis ; Atmospheric pollution ; Autonomic nervous system ; Autonomic Nervous System - drug effects ; Autonomic Nervous System - metabolism ; Biology and Life Sciences ; Cardiology ; Cardiovascular disease ; Carriers ; Confidence intervals ; Cross-Sectional Studies ; Cytokines ; Diabetes ; Ecology and Environmental Sciences ; EKG ; Electrocardiography ; Epidemiology ; Ethics ; Exposure ; Female ; Gene polymorphism ; Genetic aspects ; Genetic polymorphisms ; Genotype ; Genotypes ; Health care ; Health risk assessment ; Heart attacks ; Heart rate ; Heart Rate - drug effects ; Humans ; Inflammation ; Interleukin ; Interleukin 6 ; Interleukin-6 - genetics ; Interleukins ; Male ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Outdoor air quality ; Particulate emissions ; Particulate matter ; Particulate Matter - toxicity ; Particulates ; Pollution ; Pollution control ; Polymorphism ; Polymorphism, Genetic - genetics ; Population ; Promoter Regions, Genetic - genetics ; Public health ; Studies ; Traffic ; Variability</subject><ispartof>PloS one, 2014-08, Vol.9 (8), p.e104978</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Adam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Adam et al 2014 Adam et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-185fa2d5dc602248fa261315d3a69cb3c0fcf4f09d8c4c2cc10f6b8d5e84f5bf3</citedby><cites>FETCH-LOGICAL-c692t-185fa2d5dc602248fa261315d3a69cb3c0fcf4f09d8c4c2cc10f6b8d5e84f5bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136824/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136824/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25133672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Coulombe, Roger A.</contributor><creatorcontrib>Adam, Martin</creatorcontrib><creatorcontrib>Imboden, Medea</creatorcontrib><creatorcontrib>Boes, Eva</creatorcontrib><creatorcontrib>Schaffner, Emmanuel</creatorcontrib><creatorcontrib>Künzli, Nino</creatorcontrib><creatorcontrib>Phuleria, Harish Chandra</creatorcontrib><creatorcontrib>Kronenberg, Florian</creatorcontrib><creatorcontrib>Gaspoz, Jean-Michel</creatorcontrib><creatorcontrib>Carballo, David</creatorcontrib><creatorcontrib>Probst-Hensch, Nicole</creatorcontrib><title>Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variability</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Exposure to particulate matter (PM) has been associated with an increase in many inflammatory markers, including interleukin 6 (IL6). Air pollution exposure has also been suggested to induce an imbalance in the autonomic nervous system (ANS), such as a decrease in heart rate variability (HRV). In this study we aimed to investigate the modifying effect of polymorphisms in a major proinflammatory marker gene, interleukin 6 (IL6), on the relationship between long-term exposure to traffic-related PM10 (TPM10) and HRV.
For this cross-sectional study we analysed 1552 participants of the SAPALDIA cohort aged 50 years and older. Included were persons with valid genotype data, who underwent ambulatory 24-hr electrocardiogram monitoring, and reported on medical history and lifestyle. Main effects of annual average TPM10 and IL6 gene variants (rs1800795; rs2069827; rs2069840; rs10242595) on HRV indices and their interaction with average annual exposure to TPM10 were tested, applying a multivariable mixed linear model.
No overall association of TPM10 on HRV was found. Carriers of two proinflammatory G-alleles of the functional IL6 -174 G/C (rs1800795) polymorphism exhibited lower HRV. An inverse association between a 1 µg/m3 increment in yearly averaged TPM10 and HRV was restricted to GG genotypes at this locus with a standard deviation of normal-to-normal intervals (SDNN) (GG-carriers: -1.8%; 95% confidence interval -3.5 to 0.01; pinteraction(additive) = 0.028); and low frequency power (LF) (GG-carriers: -5.7%; 95%CI: -10.4 to -0.8; pinteraction(dominant) = 0.049).
Our results are consistent with the hypothesis that traffic-related air pollution decreases heart rate variability through inflammatory mechanisms.</description><subject>Aged</subject><subject>Air pollution</subject><subject>Analysis</subject><subject>Atherosclerosis</subject><subject>Atmospheric pollution</subject><subject>Autonomic nervous system</subject><subject>Autonomic Nervous System - drug effects</subject><subject>Autonomic Nervous System - metabolism</subject><subject>Biology and Life Sciences</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Carriers</subject><subject>Confidence intervals</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Ecology and Environmental Sciences</subject><subject>EKG</subject><subject>Electrocardiography</subject><subject>Epidemiology</subject><subject>Ethics</subject><subject>Exposure</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Health care</subject><subject>Health risk assessment</subject><subject>Heart attacks</subject><subject>Heart rate</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - genetics</subject><subject>Interleukins</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Outdoor air quality</subject><subject>Particulate emissions</subject><subject>Particulate matter</subject><subject>Particulate Matter - toxicity</subject><subject>Particulates</subject><subject>Pollution</subject><subject>Pollution control</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Population</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Public health</subject><subject>Studies</subject><subject>Traffic</subject><subject>Variability</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uL1DAYhoso7rr6D0QDguBFx5zb3gjL4mFgZcHTbUjTZCZjm3STdN35Zf49M4ddZkBBepHmzfO9TV--ryieIzhDpEJvV34KTvaz0Ts9gwjSpqofFKeoIbjkGJKHB-8nxZMYVxAyUnP-uDjBDBHCK3xa_P7sO2vW1i2ANkarBLwBEig_DN6B0ffrwYdxaeMArANpqfOSdOj19NO6koMx-MFnAfjdadC9TNa7uLQjaHX6pbUDvXeLMkMD0Lejj1PQIHmQgjTGqnJbojswypCsmjYbMMi0MZWuA0uddRA26o0MVra2t2n9tHhkZB_1s_16Vnz_8P7bxafy8urj_OL8slS8walENTMSd6xTHGJM67zhiCDWEckb1RIFjTLUwKarFVVYKQQNb-uO6Zoa1hpyVrzc-Y69j2KfeRSIMYorBhuYifmO6LxciTHYQYa18NKKreDDQmx_rNeCU8waZriUpKUNlC1rK9bKGnEu24ZW2evd_mtTO-hOaZdD6o9Mj0-cXYqFvxEUEV5jmg1e7Q2Cv550TP-48p5ayHwr64zPZmqwUYlzimqajTDO1OwvVH46PViVu87YrB8VvDkqyEzSt2khpxjF_OuX_2evfhyzrw_Y3A99WkbfT9s-OwbpDlTBxxi0uU8OQbEZmrs0xGZoxH5octmLw9Tvi-6mhPwBvXIXNA</recordid><startdate>20140818</startdate><enddate>20140818</enddate><creator>Adam, Martin</creator><creator>Imboden, Medea</creator><creator>Boes, Eva</creator><creator>Schaffner, Emmanuel</creator><creator>Künzli, Nino</creator><creator>Phuleria, Harish Chandra</creator><creator>Kronenberg, Florian</creator><creator>Gaspoz, Jean-Michel</creator><creator>Carballo, David</creator><creator>Probst-Hensch, Nicole</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140818</creationdate><title>Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variability</title><author>Adam, Martin ; Imboden, Medea ; Boes, Eva ; Schaffner, Emmanuel ; Künzli, Nino ; Phuleria, Harish Chandra ; Kronenberg, Florian ; Gaspoz, Jean-Michel ; Carballo, David ; Probst-Hensch, Nicole</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-185fa2d5dc602248fa261315d3a69cb3c0fcf4f09d8c4c2cc10f6b8d5e84f5bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Air pollution</topic><topic>Analysis</topic><topic>Atherosclerosis</topic><topic>Atmospheric pollution</topic><topic>Autonomic nervous system</topic><topic>Autonomic Nervous System - drug effects</topic><topic>Autonomic Nervous System - metabolism</topic><topic>Biology and Life Sciences</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Carriers</topic><topic>Confidence intervals</topic><topic>Cross-Sectional Studies</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Ecology and Environmental Sciences</topic><topic>EKG</topic><topic>Electrocardiography</topic><topic>Epidemiology</topic><topic>Ethics</topic><topic>Exposure</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Health care</topic><topic>Health risk assessment</topic><topic>Heart attacks</topic><topic>Heart rate</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - genetics</topic><topic>Interleukins</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Outdoor air quality</topic><topic>Particulate emissions</topic><topic>Particulate matter</topic><topic>Particulate Matter - 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Air pollution exposure has also been suggested to induce an imbalance in the autonomic nervous system (ANS), such as a decrease in heart rate variability (HRV). In this study we aimed to investigate the modifying effect of polymorphisms in a major proinflammatory marker gene, interleukin 6 (IL6), on the relationship between long-term exposure to traffic-related PM10 (TPM10) and HRV.
For this cross-sectional study we analysed 1552 participants of the SAPALDIA cohort aged 50 years and older. Included were persons with valid genotype data, who underwent ambulatory 24-hr electrocardiogram monitoring, and reported on medical history and lifestyle. Main effects of annual average TPM10 and IL6 gene variants (rs1800795; rs2069827; rs2069840; rs10242595) on HRV indices and their interaction with average annual exposure to TPM10 were tested, applying a multivariable mixed linear model.
No overall association of TPM10 on HRV was found. Carriers of two proinflammatory G-alleles of the functional IL6 -174 G/C (rs1800795) polymorphism exhibited lower HRV. An inverse association between a 1 µg/m3 increment in yearly averaged TPM10 and HRV was restricted to GG genotypes at this locus with a standard deviation of normal-to-normal intervals (SDNN) (GG-carriers: -1.8%; 95% confidence interval -3.5 to 0.01; pinteraction(additive) = 0.028); and low frequency power (LF) (GG-carriers: -5.7%; 95%CI: -10.4 to -0.8; pinteraction(dominant) = 0.049).
Our results are consistent with the hypothesis that traffic-related air pollution decreases heart rate variability through inflammatory mechanisms.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25133672</pmid><doi>10.1371/journal.pone.0104978</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-08, Vol.9 (8), p.e104978 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1554275090 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Aged Air pollution Analysis Atherosclerosis Atmospheric pollution Autonomic nervous system Autonomic Nervous System - drug effects Autonomic Nervous System - metabolism Biology and Life Sciences Cardiology Cardiovascular disease Carriers Confidence intervals Cross-Sectional Studies Cytokines Diabetes Ecology and Environmental Sciences EKG Electrocardiography Epidemiology Ethics Exposure Female Gene polymorphism Genetic aspects Genetic polymorphisms Genotype Genotypes Health care Health risk assessment Heart attacks Heart rate Heart Rate - drug effects Humans Inflammation Interleukin Interleukin 6 Interleukin-6 - genetics Interleukins Male Medicine Medicine and Health Sciences Middle Aged Mortality Outdoor air quality Particulate emissions Particulate matter Particulate Matter - toxicity Particulates Pollution Pollution control Polymorphism Polymorphism, Genetic - genetics Population Promoter Regions, Genetic - genetics Public health Studies Traffic Variability |
| title | Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variability |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T05%3A04%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Modifying%20effect%20of%20a%20common%20polymorphism%20in%20the%20interleukin-6%20promoter%20on%20the%20relationship%20between%20long-term%20exposure%20to%20traffic-related%20particulate%20matter%20and%20heart%20rate%20variability&rft.jtitle=PloS%20one&rft.au=Adam,%20Martin&rft.date=2014-08-18&rft.volume=9&rft.issue=8&rft.spage=e104978&rft.pages=e104978-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0104978&rft_dat=%3Cgale_plos_%3EA418424322%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1554275090&rft_id=info:pmid/25133672&rft_galeid=A418424322&rft_doaj_id=oai_doaj_org_article_642595f6aa3b490ab5b75ba8166ab947&rfr_iscdi=true |