Dopamine D2-like receptors modulate unconditioned fear: role of the inferior colliculus
A reduction of dopamine release or D2 receptor blockade in the terminal fields of the mesolimbic system clearly reduces conditioned fear. Injections of haloperidol, a preferential D2 receptor antagonist, into the inferior colliculus (IC) enhance the processing of unconditioned aversive information....
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| Veröffentlicht in: | PloS one 2014-08, Vol.9 (8), p.e104228-e104228 |
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| creator | de Oliveira, Amanda Ribeiro Colombo, Ana Caroline Muthuraju, Sangu Almada, Rafael Carvalho Brandão, Marcus Lira |
| description | A reduction of dopamine release or D2 receptor blockade in the terminal fields of the mesolimbic system clearly reduces conditioned fear. Injections of haloperidol, a preferential D2 receptor antagonist, into the inferior colliculus (IC) enhance the processing of unconditioned aversive information. However, a clear characterization of the interplay of D2 receptors in the mediation of unconditioned and conditioned fear is still lacking.
The present study investigated the effects of intra-IC injections of the D2 receptor-selective antagonist sulpiride on behavior in the elevated plus maze (EPM), auditory-evoked potentials (AEPs) to loud sounds recorded from the IC, fear-potentiated startle (FPS), and conditioned freezing.
Intra-IC injections of sulpiride caused clear proaversive effects in the EPM and enhanced AEPs induced by loud auditory stimuli. Intra-IC sulpiride administration did not affect FPS or conditioned freezing.
Dopamine D2-like receptors of the inferior colliculus play a role in the modulation of unconditioned aversive information but not in the fear-potentiated startle response. |
| doi_str_mv | 10.1371/journal.pone.0104228 |
| format | Article |
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The present study investigated the effects of intra-IC injections of the D2 receptor-selective antagonist sulpiride on behavior in the elevated plus maze (EPM), auditory-evoked potentials (AEPs) to loud sounds recorded from the IC, fear-potentiated startle (FPS), and conditioned freezing.
Intra-IC injections of sulpiride caused clear proaversive effects in the EPM and enhanced AEPs induced by loud auditory stimuli. Intra-IC sulpiride administration did not affect FPS or conditioned freezing.
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The present study investigated the effects of intra-IC injections of the D2 receptor-selective antagonist sulpiride on behavior in the elevated plus maze (EPM), auditory-evoked potentials (AEPs) to loud sounds recorded from the IC, fear-potentiated startle (FPS), and conditioned freezing.
Intra-IC injections of sulpiride caused clear proaversive effects in the EPM and enhanced AEPs induced by loud auditory stimuli. Intra-IC sulpiride administration did not affect FPS or conditioned freezing.
Dopamine D2-like receptors of the inferior colliculus play a role in the modulation of unconditioned aversive information but not in the fear-potentiated startle response.</description><subject>Acoustics</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Auditory evoked potentials</subject><subject>Auditory stimuli</subject><subject>Biology and Life Sciences</subject><subject>Colliculus</subject><subject>Conditioning</subject><subject>Conditioning (Psychology)</subject><subject>Dopamine</subject><subject>Dopamine D2 Receptor Antagonists - pharmacology</subject><subject>Dopamine D2 receptors</subject><subject>Electrodes</subject><subject>Evoked Potentials, Auditory</subject><subject>Fear</subject><subject>Fear - physiology</subject><subject>Fear conditioning</subject><subject>Freezing</subject><subject>Haloperidol</subject><subject>Haloperidol - pharmacology</subject><subject>Inferior Colliculi - metabolism</subject><subject>Inferior colliculus</subject><subject>Information processing</subject><subject>Light</subject><subject>Male</subject><subject>Mesolimbic system</subject><subject>Owls</subject><subject>Rats, Wistar</subject><subject>Receptors</subject><subject>Receptors, Dopamine D2 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Oliveira, Amanda Ribeiro</au><au>Colombo, Ana Caroline</au><au>Muthuraju, Sangu</au><au>Almada, Rafael Carvalho</au><au>Brandão, Marcus Lira</au><au>Jhou, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopamine D2-like receptors modulate unconditioned fear: role of the inferior colliculus</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-08-18</date><risdate>2014</risdate><volume>9</volume><issue>8</issue><spage>e104228</spage><epage>e104228</epage><pages>e104228-e104228</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>A reduction of dopamine release or D2 receptor blockade in the terminal fields of the mesolimbic system clearly reduces conditioned fear. Injections of haloperidol, a preferential D2 receptor antagonist, into the inferior colliculus (IC) enhance the processing of unconditioned aversive information. However, a clear characterization of the interplay of D2 receptors in the mediation of unconditioned and conditioned fear is still lacking.
The present study investigated the effects of intra-IC injections of the D2 receptor-selective antagonist sulpiride on behavior in the elevated plus maze (EPM), auditory-evoked potentials (AEPs) to loud sounds recorded from the IC, fear-potentiated startle (FPS), and conditioned freezing.
Intra-IC injections of sulpiride caused clear proaversive effects in the EPM and enhanced AEPs induced by loud auditory stimuli. Intra-IC sulpiride administration did not affect FPS or conditioned freezing.
Dopamine D2-like receptors of the inferior colliculus play a role in the modulation of unconditioned aversive information but not in the fear-potentiated startle response.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25133693</pmid><doi>10.1371/journal.pone.0104228</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acoustics Amino acids Animals Anxiety Auditory evoked potentials Auditory stimuli Biology and Life Sciences Colliculus Conditioning Conditioning (Psychology) Dopamine Dopamine D2 Receptor Antagonists - pharmacology Dopamine D2 receptors Electrodes Evoked Potentials, Auditory Fear Fear - physiology Fear conditioning Freezing Haloperidol Haloperidol - pharmacology Inferior Colliculi - metabolism Inferior colliculus Information processing Light Male Mesolimbic system Owls Rats, Wistar Receptors Receptors, Dopamine D2 - physiology Reflex, Startle Rodents Startle response Sulpiride Tonic immobility |
| title | Dopamine D2-like receptors modulate unconditioned fear: role of the inferior colliculus |
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