Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial
The effect of tranexamic acid (TXA) on bleeding and improvement of surgical field during functional endoscopic sinus surgery (FESS) is not clear yet. This study was conducted to answer this question. This trial was conducted on 60 patients with chronic sinusitis at Beasat Hospital, Hamadan, Iran, fr...
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| description | The effect of tranexamic acid (TXA) on bleeding and improvement of surgical field during functional endoscopic sinus surgery (FESS) is not clear yet. This study was conducted to answer this question.
This trial was conducted on 60 patients with chronic sinusitis at Beasat Hospital, Hamadan, Iran, from April to November 2013. Thirty patients in the intervention group received three pledgets soaked with TXA 5% and phenylephrine 0.5% for 10 minutes in each nasal cavity before surgery. Thirty patients in the control group received phenylephrine 0.5% with the same way. The amount of bleeding and the quality of surgical field were evaluated at 15, 30, and 45 minutes after the start of surgery using Boezaart grading.
The quality of the surgical field in the intervention group compared to the control group was significantly better in the first quarter (P = 0.002) and the second quarter (P = 0.003) but not in the third quarter (P = 0.163). Furthermore, the amount of bleeding was much less during all periods in the intervention group than in the control group (P = 0.001).
Topical TXA can efficiently reduce bleeding and improve the surgical field in FESS in patients with rhinosinusitis. Based on these findings, topical TXA may be a useful method for providing a suitable surgical field during the first 30 minutes after use.
Iranian Registry of Clinical Trials IRCT201212139014N15. |
| doi_str_mv | 10.1371/journal.pone.0104477 |
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This trial was conducted on 60 patients with chronic sinusitis at Beasat Hospital, Hamadan, Iran, from April to November 2013. Thirty patients in the intervention group received three pledgets soaked with TXA 5% and phenylephrine 0.5% for 10 minutes in each nasal cavity before surgery. Thirty patients in the control group received phenylephrine 0.5% with the same way. The amount of bleeding and the quality of surgical field were evaluated at 15, 30, and 45 minutes after the start of surgery using Boezaart grading.
The quality of the surgical field in the intervention group compared to the control group was significantly better in the first quarter (P = 0.002) and the second quarter (P = 0.003) but not in the third quarter (P = 0.163). Furthermore, the amount of bleeding was much less during all periods in the intervention group than in the control group (P = 0.001).
Topical TXA can efficiently reduce bleeding and improve the surgical field in FESS in patients with rhinosinusitis. Based on these findings, topical TXA may be a useful method for providing a suitable surgical field during the first 30 minutes after use.
Iranian Registry of Clinical Trials IRCT201212139014N15.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0104477</identifier><identifier>PMID: 25133491</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Administration, Topical ; Adolescent ; Adult ; Antifibrinolytic agents ; Antifibrinolytic Agents - administration & dosage ; Binding sites ; Bleeding ; Blood Loss, Surgical - prevention & control ; Bone surgery ; Chronic Disease ; Chronic illnesses ; Clinical trials ; Drug dosages ; Drug Therapy, Combination ; Endoscopy ; Epistaxis - prevention & control ; Evaluation ; Female ; Hemostasis, Surgical ; Hemostatic agents ; Humans ; Hypertension ; Intervention ; Joint surgery ; Male ; Medical research ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Nose ; Patients ; Phenylephrine ; Phenylephrine - therapeutic use ; Rhinitis ; Rhinitis - surgery ; Rhinosinusitis ; Sinus ; Sinuses ; Sinusitis ; Sinusitis - surgery ; Surgery ; Systematic review ; Thoracic surgery ; Throat surgery ; Tranexamic Acid - administration & dosage ; Treatment Outcome ; Vasoconstrictor Agents - therapeutic use ; Young Adult</subject><ispartof>PloS one, 2014-08, Vol.9 (8), p.e104477-e104477</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Jahanshahi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Jahanshahi et al 2014 Jahanshahi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b15b1e8ed737fbe87beaac013643408633a2e8df05a4c073023f7ee6eb10d1fc3</citedby><cites>FETCH-LOGICAL-c692t-b15b1e8ed737fbe87beaac013643408633a2e8df05a4c073023f7ee6eb10d1fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136784/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136784/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25133491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wang, Xiaoying</contributor><creatorcontrib>Jahanshahi, Javaneh</creatorcontrib><creatorcontrib>Hashemian, Farnaz</creatorcontrib><creatorcontrib>Pazira, Sara</creatorcontrib><creatorcontrib>Bakhshaei, Mohammad Hossein</creatorcontrib><creatorcontrib>Farahani, Farhad</creatorcontrib><creatorcontrib>Abasi, Ruholah</creatorcontrib><creatorcontrib>Poorolajal, Jalal</creatorcontrib><title>Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The effect of tranexamic acid (TXA) on bleeding and improvement of surgical field during functional endoscopic sinus surgery (FESS) is not clear yet. This study was conducted to answer this question.
This trial was conducted on 60 patients with chronic sinusitis at Beasat Hospital, Hamadan, Iran, from April to November 2013. Thirty patients in the intervention group received three pledgets soaked with TXA 5% and phenylephrine 0.5% for 10 minutes in each nasal cavity before surgery. Thirty patients in the control group received phenylephrine 0.5% with the same way. The amount of bleeding and the quality of surgical field were evaluated at 15, 30, and 45 minutes after the start of surgery using Boezaart grading.
The quality of the surgical field in the intervention group compared to the control group was significantly better in the first quarter (P = 0.002) and the second quarter (P = 0.003) but not in the third quarter (P = 0.163). Furthermore, the amount of bleeding was much less during all periods in the intervention group than in the control group (P = 0.001).
Topical TXA can efficiently reduce bleeding and improve the surgical field in FESS in patients with rhinosinusitis. Based on these findings, topical TXA may be a useful method for providing a suitable surgical field during the first 30 minutes after use.
Iranian Registry of Clinical Trials IRCT201212139014N15.</description><subject>Acids</subject><subject>Administration, Topical</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Antifibrinolytic agents</subject><subject>Antifibrinolytic Agents - administration & dosage</subject><subject>Binding sites</subject><subject>Bleeding</subject><subject>Blood Loss, Surgical - prevention & control</subject><subject>Bone surgery</subject><subject>Chronic Disease</subject><subject>Chronic illnesses</subject><subject>Clinical trials</subject><subject>Drug dosages</subject><subject>Drug Therapy, Combination</subject><subject>Endoscopy</subject><subject>Epistaxis - prevention & control</subject><subject>Evaluation</subject><subject>Female</subject><subject>Hemostasis, Surgical</subject><subject>Hemostatic agents</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Intervention</subject><subject>Joint surgery</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Nose</subject><subject>Patients</subject><subject>Phenylephrine</subject><subject>Phenylephrine - therapeutic use</subject><subject>Rhinitis</subject><subject>Rhinitis - surgery</subject><subject>Rhinosinusitis</subject><subject>Sinus</subject><subject>Sinuses</subject><subject>Sinusitis</subject><subject>Sinusitis - surgery</subject><subject>Surgery</subject><subject>Systematic review</subject><subject>Thoracic surgery</subject><subject>Throat surgery</subject><subject>Tranexamic Acid - administration & dosage</subject><subject>Treatment Outcome</subject><subject>Vasoconstrictor Agents - therapeutic use</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9GAIHqxazLJfKwXQilVFwoFv25DJjnZTckm2ySjXX-hP8vM7rTsSi9kLmbIPO-b95zkFMVzgqeENuTdle-DE3a69g6mmGDGmuZBcUxmtJzUJaYP976PiicxXmFc0bauHxdHZUUoZTNyXPw51xpkQl6j5NdGCotSEA5uxMpIJKRRyDvUWQBl3AIJp9B1L6xJm0ES-7DYarQBq5DqwwDp3slkfA6HwCkf5WCMonF93CogbJBxaC2SAZci-mXSEsll8C5jYWmc37ImmfgeiZzHrC3kDCZvnrMpvzK_QSGZF8bARtinxSMtbIRn4_uk-P7x_NvZ58nF5af52enFRNazMk06UnUEWlANbXQHbdOBEBITWjPKcFtTKkpolcaVYBI3FJdUNwA1dAQroiU9KV7ufNfWRz4eQuSkqljZsJo1mZjvCOXFFV8HsxJhw70wfLvgw4KLkIy0wFVNSwF1Q6pGsxyhbctKi67GpaYzTVj2-jDu1ncrUDL3Kwh7YHr4x5klX_ifnOWKmnYweDMaBH_dQ0x8ZaIEa_MZ-36Xe8ZwNWsz-uof9P7qRmohcgHGaZ_3lYMpP2WkZSVjeKCm91D5UZDvVb6x2uT1A8HbA0FmEtykhehj5POvX_6fvfxxyL7eY5cgbFpGb_vhfsZDkO1AGXyMAfRdkwnmw8DddoMPA8fHgcuyF_sHdCe6nTD6F4MrKs4</recordid><startdate>20140818</startdate><enddate>20140818</enddate><creator>Jahanshahi, Javaneh</creator><creator>Hashemian, Farnaz</creator><creator>Pazira, Sara</creator><creator>Bakhshaei, Mohammad Hossein</creator><creator>Farahani, Farhad</creator><creator>Abasi, Ruholah</creator><creator>Poorolajal, Jalal</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140818</creationdate><title>Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial</title><author>Jahanshahi, Javaneh ; Hashemian, Farnaz ; Pazira, Sara ; Bakhshaei, Mohammad Hossein ; Farahani, Farhad ; Abasi, Ruholah ; Poorolajal, Jalal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-b15b1e8ed737fbe87beaac013643408633a2e8df05a4c073023f7ee6eb10d1fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acids</topic><topic>Administration, Topical</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Antifibrinolytic agents</topic><topic>Antifibrinolytic Agents - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jahanshahi, Javaneh</au><au>Hashemian, Farnaz</au><au>Pazira, Sara</au><au>Bakhshaei, Mohammad Hossein</au><au>Farahani, Farhad</au><au>Abasi, Ruholah</au><au>Poorolajal, Jalal</au><au>Wang, Xiaoying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-08-18</date><risdate>2014</risdate><volume>9</volume><issue>8</issue><spage>e104477</spage><epage>e104477</epage><pages>e104477-e104477</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The effect of tranexamic acid (TXA) on bleeding and improvement of surgical field during functional endoscopic sinus surgery (FESS) is not clear yet. This study was conducted to answer this question.
This trial was conducted on 60 patients with chronic sinusitis at Beasat Hospital, Hamadan, Iran, from April to November 2013. Thirty patients in the intervention group received three pledgets soaked with TXA 5% and phenylephrine 0.5% for 10 minutes in each nasal cavity before surgery. Thirty patients in the control group received phenylephrine 0.5% with the same way. The amount of bleeding and the quality of surgical field were evaluated at 15, 30, and 45 minutes after the start of surgery using Boezaart grading.
The quality of the surgical field in the intervention group compared to the control group was significantly better in the first quarter (P = 0.002) and the second quarter (P = 0.003) but not in the third quarter (P = 0.163). Furthermore, the amount of bleeding was much less during all periods in the intervention group than in the control group (P = 0.001).
Topical TXA can efficiently reduce bleeding and improve the surgical field in FESS in patients with rhinosinusitis. Based on these findings, topical TXA may be a useful method for providing a suitable surgical field during the first 30 minutes after use.
Iranian Registry of Clinical Trials IRCT201212139014N15.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25133491</pmid><doi>10.1371/journal.pone.0104477</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-08, Vol.9 (8), p.e104477-e104477 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1554274647 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acids Administration, Topical Adolescent Adult Antifibrinolytic agents Antifibrinolytic Agents - administration & dosage Binding sites Bleeding Blood Loss, Surgical - prevention & control Bone surgery Chronic Disease Chronic illnesses Clinical trials Drug dosages Drug Therapy, Combination Endoscopy Epistaxis - prevention & control Evaluation Female Hemostasis, Surgical Hemostatic agents Humans Hypertension Intervention Joint surgery Male Medical research Medicine Medicine and Health Sciences Middle Aged Nose Patients Phenylephrine Phenylephrine - therapeutic use Rhinitis Rhinitis - surgery Rhinosinusitis Sinus Sinuses Sinusitis Sinusitis - surgery Surgery Systematic review Thoracic surgery Throat surgery Tranexamic Acid - administration & dosage Treatment Outcome Vasoconstrictor Agents - therapeutic use Young Adult |
| title | Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T18%3A02%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20topical%20tranexamic%20acid%20on%20bleeding%20and%20quality%20of%20surgical%20field%20during%20functional%20endoscopic%20sinus%20surgery%20in%20patients%20with%20chronic%20rhinosinusitis:%20a%20triple%20blind%20randomized%20clinical%20trial&rft.jtitle=PloS%20one&rft.au=Jahanshahi,%20Javaneh&rft.date=2014-08-18&rft.volume=9&rft.issue=8&rft.spage=e104477&rft.epage=e104477&rft.pages=e104477-e104477&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0104477&rft_dat=%3Cgale_plos_%3EA418424407%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1554274647&rft_id=info:pmid/25133491&rft_galeid=A418424407&rft_doaj_id=oai_doaj_org_article_d632ae67157f43648825fab602f39f14&rfr_iscdi=true |