Cadherin cytoplasmic domains inhibit the cell surface localization of endogenous E-cadherin, blocking desmosome and tight junction formation and inducing cell dissociation

The downregulation of E-cadherin function has fundamental consequences with respect to cancer progression, and occurs as part of the epithelial-mesenchymal transition (EMT). In this study, we show that the expression of the Discosoma sp. red fluorescent protein (DsRed)-tagged cadherin cytoplasmic do...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e105313-e105313
Hauptverfasser:	Ozawa, Masayuki, Kobayashi, Wakako
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals beta Catenin - metabolism Biochemistry Biology and Life Sciences Cadherins - chemistry Cadherins - genetics Cadherins - metabolism Cancer Catenin Cell Adhesion Cell adhesion & migration Cell Communication - genetics Cell Line Cell Membrane - metabolism Cell migration Cell surface Chimeras Cloning Cytoplasm - metabolism Deoxyribonucleic acid Desmosomes - metabolism Dissociation DNA Down-regulation E-cadherin Epithelial-Mesenchymal Transition - genetics Fluorescence gamma Catenin - metabolism Gene Expression Genes, Reporter Humans Inhibition Localization Markers Medical research Medicine and Health Sciences Mesenchyme Molecular biology Morphology Mutation Protein Binding Protein Interaction Domains and Motifs - genetics Protein Transport Proteins Red fluorescent protein Stem cells Tight Junctions - metabolism α-Catenin β-Catenin
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