Dysfunction of bone marrow vascular niche in acute graft-versus-host disease after MHC-haploidentical bone marrow transplantation

Acute graft-versus-host disease (aGvHD) is the most common complication of allogeneic hematopoietic stem cell transplantation (HSCT), which is often accompanied by impaired hematopoietic reconstitution. Sinusoidal endothelial cells (SECs) constitute bone marrow (BM) vascular niche that plays an impo...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e104607-e104607
Hauptverfasser:	Yao, Yonghua, Song, Xianmin, Cheng, Hui, Tang, Gusheng, Hu, Xiaoxia, Zhou, Hong, Wang, Jianmin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis B cells Blood Bone marrow Bone marrow transplantation Bone Marrow Transplantation - adverse effects Caspase Caspase 3 - metabolism Caspase-3 CD4 antigen CD4-Positive T-Lymphocytes - metabolism CD8 antigen Cell self-renewal Cytokines Endothelial cells Endothelial Cells - cytology Enzyme-Linked Immunosorbent Assay fas Receptor - metabolism FasL protein Flow Cytometry Graft versus host disease Graft vs Host Disease - etiology Graft vs Host Disease - physiopathology Graft-versus-host reaction Hematology Hematopoiesis Hematopoiesis - physiology Hematopoietic stem cells Hematopoietic Stem Cells - cytology Immunohistochemistry Kaplan-Meier Estimate Levels Ligands Lymphocytes Lymphocytes T Major histocompatibility complex Major Histocompatibility Complex - genetics Medical prognosis Medicine and Health Sciences Mice Real-Time Polymerase Chain Reaction Rodents Stem cell transplantation Stem cells Survival analysis Target marketing Transplantation Transplantation, Homologous Transplants & implants Vascular endothelial growth factor
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