Vitamin D status among Thai school children and the association with 1,25-Dihydroxyvitamin D and parathyroid hormone levels
In several low latitude countries, vitamin D deficiency is emerging as a public health issue. Adequate vitamin D is essential for bone health in rapidly growing children. In the Thai population, little is known about serum 25-hydroxyvitamin D [25(OH)D] status of infants and children. Moreover, the a...
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| description | In several low latitude countries, vitamin D deficiency is emerging as a public health issue. Adequate vitamin D is essential for bone health in rapidly growing children. In the Thai population, little is known about serum 25-hydroxyvitamin D [25(OH)D] status of infants and children. Moreover, the association between 25(OH)D and the biological active form of 1,25-dihydroxyvitamin D [1,25(OH)]2D is not clear. The specific aims of this study were to characterize circulating serum 25(OH)D, 1,25(OH)2D and their determinants including parathyroid hormone (PTH), age, sex, height and body mass index (BMI) in 529 school-aged Thai children aged 6-14 y. Adjusted linear regression analysis was performed to examine the impact of age and BMI, and its interaction with sex, on serum 25(OH)D concentrations and 1,25(OH)2D concentrations. Serum 25(OH)D, 1,25(OH)2D and PTH concentrations (geometric mean ± geometric SD) were 72.7±1.2 nmol/L, 199.1±1.3 pmol/L and 35.0±1.5 ng/L, respectively. Only 4% (21 of 529) participants had a serum 25(OH)D level below 50 nmol/L. There was statistically significant evidence for an interaction between sex and age with regard to 25(OH)D concentrations. Specifically, 25(OH)D concentrations were 19% higher in males. Moreover, females experienced a statistically significant 4% decline in serum 25(OH)D levels for each increasing year of age (P = 0.001); no decline was seen in male participants with increasing age (P = 0.93). When BMI, age, sex, height and serum 25(OH)D were individually regressed on 1,25(OH)2D, height and sex were associated with 1,25(OH)2D with females exhibiting statistically significantly higher serum 1,25(OH)2D levels compared with males (P |
| doi_str_mv | 10.1371/journal.pone.0104825 |
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Adequate vitamin D is essential for bone health in rapidly growing children. In the Thai population, little is known about serum 25-hydroxyvitamin D [25(OH)D] status of infants and children. Moreover, the association between 25(OH)D and the biological active form of 1,25-dihydroxyvitamin D [1,25(OH)]2D is not clear. The specific aims of this study were to characterize circulating serum 25(OH)D, 1,25(OH)2D and their determinants including parathyroid hormone (PTH), age, sex, height and body mass index (BMI) in 529 school-aged Thai children aged 6-14 y. Adjusted linear regression analysis was performed to examine the impact of age and BMI, and its interaction with sex, on serum 25(OH)D concentrations and 1,25(OH)2D concentrations. Serum 25(OH)D, 1,25(OH)2D and PTH concentrations (geometric mean ± geometric SD) were 72.7±1.2 nmol/L, 199.1±1.3 pmol/L and 35.0±1.5 ng/L, respectively. Only 4% (21 of 529) participants had a serum 25(OH)D level below 50 nmol/L. There was statistically significant evidence for an interaction between sex and age with regard to 25(OH)D concentrations. Specifically, 25(OH)D concentrations were 19% higher in males. Moreover, females experienced a statistically significant 4% decline in serum 25(OH)D levels for each increasing year of age (P = 0.001); no decline was seen in male participants with increasing age (P = 0.93). When BMI, age, sex, height and serum 25(OH)D were individually regressed on 1,25(OH)2D, height and sex were associated with 1,25(OH)2D with females exhibiting statistically significantly higher serum 1,25(OH)2D levels compared with males (P<0.001). Serum 1,25(OH)2D among our sample of children exhibiting fairly sufficient vitamin D status were higher than previous reports suggesting an adaptive mechanism to maximize calcium absorption.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0104825</identifier><identifier>PMID: 25111832</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>25-Hydroxyvitamin D ; Adolescent ; Adults ; Age ; Age Factors ; Biology and life sciences ; Body Height ; Body mass ; Body Mass Index ; Body size ; Calcium ; Calcium absorption ; Calcium, Dietary ; Child ; Children ; Children & youth ; Diet ; Female ; Females ; Girls ; Humans ; Infants ; Male ; Males ; Medicine and Health Sciences ; Metabolism ; Metabolites ; Nutrient deficiency ; Nutrition research ; Parathyroid ; Parathyroid hormone ; Parathyroid Hormone - blood ; Public health ; Regression analysis ; Schools ; Sex ; Sex Factors ; Sociodemographics ; Socioeconomic Factors ; Statistical analysis ; Statistical significance ; Students ; Teenagers ; Thailand ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin deficiency</subject><ispartof>PloS one, 2014-08, Vol.9 (8), p.e104825-e104825</ispartof><rights>2014 Houghton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Houghton et al 2014 Houghton et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-96ee9d7afabd70535917ac6cddd4738ee98ee30bbce3a7d7b7975387b9543bf53</citedby><cites>FETCH-LOGICAL-c526t-96ee9d7afabd70535917ac6cddd4738ee98ee30bbce3a7d7b7975387b9543bf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128742/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128742/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25111832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Houghton, Lisa A</creatorcontrib><creatorcontrib>Gray, Andrew R</creatorcontrib><creatorcontrib>Harper, Michelle J</creatorcontrib><creatorcontrib>Winichagoon, Pattanee</creatorcontrib><creatorcontrib>Pongcharoen, Tippawan</creatorcontrib><creatorcontrib>Gowachirapant, Sueppong</creatorcontrib><creatorcontrib>Gibson, Rosalind S</creatorcontrib><title>Vitamin D status among Thai school children and the association with 1,25-Dihydroxyvitamin D and parathyroid hormone levels</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In several low latitude countries, vitamin D deficiency is emerging as a public health issue. Adequate vitamin D is essential for bone health in rapidly growing children. In the Thai population, little is known about serum 25-hydroxyvitamin D [25(OH)D] status of infants and children. Moreover, the association between 25(OH)D and the biological active form of 1,25-dihydroxyvitamin D [1,25(OH)]2D is not clear. The specific aims of this study were to characterize circulating serum 25(OH)D, 1,25(OH)2D and their determinants including parathyroid hormone (PTH), age, sex, height and body mass index (BMI) in 529 school-aged Thai children aged 6-14 y. Adjusted linear regression analysis was performed to examine the impact of age and BMI, and its interaction with sex, on serum 25(OH)D concentrations and 1,25(OH)2D concentrations. Serum 25(OH)D, 1,25(OH)2D and PTH concentrations (geometric mean ± geometric SD) were 72.7±1.2 nmol/L, 199.1±1.3 pmol/L and 35.0±1.5 ng/L, respectively. Only 4% (21 of 529) participants had a serum 25(OH)D level below 50 nmol/L. There was statistically significant evidence for an interaction between sex and age with regard to 25(OH)D concentrations. Specifically, 25(OH)D concentrations were 19% higher in males. Moreover, females experienced a statistically significant 4% decline in serum 25(OH)D levels for each increasing year of age (P = 0.001); no decline was seen in male participants with increasing age (P = 0.93). When BMI, age, sex, height and serum 25(OH)D were individually regressed on 1,25(OH)2D, height and sex were associated with 1,25(OH)2D with females exhibiting statistically significantly higher serum 1,25(OH)2D levels compared with males (P<0.001). Serum 1,25(OH)2D among our sample of children exhibiting fairly sufficient vitamin D status were higher than previous reports suggesting an adaptive mechanism to maximize calcium absorption.</description><subject>25-Hydroxyvitamin D</subject><subject>Adolescent</subject><subject>Adults</subject><subject>Age</subject><subject>Age Factors</subject><subject>Biology and life sciences</subject><subject>Body Height</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Calcium</subject><subject>Calcium absorption</subject><subject>Calcium, Dietary</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Diet</subject><subject>Female</subject><subject>Females</subject><subject>Girls</subject><subject>Humans</subject><subject>Infants</subject><subject>Male</subject><subject>Males</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Nutrient deficiency</subject><subject>Nutrition research</subject><subject>Parathyroid</subject><subject>Parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Schools</subject><subject>Sex</subject><subject>Sex Factors</subject><subject>Sociodemographics</subject><subject>Socioeconomic Factors</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><subject>Students</subject><subject>Teenagers</subject><subject>Thailand</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin deficiency</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUl2L1DAUDaK46-g_EA344oMdm6Zp2hdBdv1YWPBl9TXcfHSaIdOMSTo6-OfN7HSHXZEQEnLPObnnchB6ScoloZy8X_spjOCWWz-aZUnKuq3YI3ROOloVTVXSx_fuZ-hZjOuyZLRtmqforGKEkJZW5-jPD5tgY0d8iWOCNEUMGz-u8M0AFkc1eO-wGqzTwYwYRo3TYDDE6JWFZP2If9k0YPKuYsWlHfY6-N_73UnyQNhCgDTsg7caDz5kdYOd2RkXn6MnPbhoXsznAn3__Onm4mtx_e3L1cXH60KxqklF1xjTaQ49SM2zBdYRDqpRWuua0zYX86allMpQ4JpL3vFslMuO1VT2jC7Q66Pu1vko5rlFQViWr2uWUQt0dURoD2uxDXYDYS88WHH74MNKQEhWOSN60vdtJ9tGE103WskGNFFUtjKPV5Yka32Yf5vkxmhlxhTAPRB9WBntIFZ-J2pStbyussDbWSD4n5OJSWxsVMY5GI2fbvumpGR5Zeibf6D_d1cfUSr4GIPpT82QUhyydMcShyyJOUuZ9uq-kRPpLjz0Lzy9yhY</recordid><startdate>20140811</startdate><enddate>20140811</enddate><creator>Houghton, Lisa A</creator><creator>Gray, Andrew R</creator><creator>Harper, Michelle J</creator><creator>Winichagoon, Pattanee</creator><creator>Pongcharoen, Tippawan</creator><creator>Gowachirapant, Sueppong</creator><creator>Gibson, Rosalind S</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140811</creationdate><title>Vitamin D status among Thai school children and the association with 1,25-Dihydroxyvitamin D and parathyroid hormone levels</title><author>Houghton, Lisa A ; Gray, Andrew R ; Harper, Michelle J ; Winichagoon, Pattanee ; Pongcharoen, Tippawan ; Gowachirapant, Sueppong ; Gibson, Rosalind S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-96ee9d7afabd70535917ac6cddd4738ee98ee30bbce3a7d7b7975387b9543bf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Adolescent</topic><topic>Adults</topic><topic>Age</topic><topic>Age Factors</topic><topic>Biology and life sciences</topic><topic>Body Height</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Calcium</topic><topic>Calcium absorption</topic><topic>Calcium, Dietary</topic><topic>Child</topic><topic>Children</topic><topic>Children & youth</topic><topic>Diet</topic><topic>Female</topic><topic>Females</topic><topic>Girls</topic><topic>Humans</topic><topic>Infants</topic><topic>Male</topic><topic>Males</topic><topic>Medicine and Health Sciences</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Nutrient deficiency</topic><topic>Nutrition research</topic><topic>Parathyroid</topic><topic>Parathyroid hormone</topic><topic>Parathyroid Hormone - 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Adequate vitamin D is essential for bone health in rapidly growing children. In the Thai population, little is known about serum 25-hydroxyvitamin D [25(OH)D] status of infants and children. Moreover, the association between 25(OH)D and the biological active form of 1,25-dihydroxyvitamin D [1,25(OH)]2D is not clear. The specific aims of this study were to characterize circulating serum 25(OH)D, 1,25(OH)2D and their determinants including parathyroid hormone (PTH), age, sex, height and body mass index (BMI) in 529 school-aged Thai children aged 6-14 y. Adjusted linear regression analysis was performed to examine the impact of age and BMI, and its interaction with sex, on serum 25(OH)D concentrations and 1,25(OH)2D concentrations. Serum 25(OH)D, 1,25(OH)2D and PTH concentrations (geometric mean ± geometric SD) were 72.7±1.2 nmol/L, 199.1±1.3 pmol/L and 35.0±1.5 ng/L, respectively. Only 4% (21 of 529) participants had a serum 25(OH)D level below 50 nmol/L. There was statistically significant evidence for an interaction between sex and age with regard to 25(OH)D concentrations. Specifically, 25(OH)D concentrations were 19% higher in males. Moreover, females experienced a statistically significant 4% decline in serum 25(OH)D levels for each increasing year of age (P = 0.001); no decline was seen in male participants with increasing age (P = 0.93). When BMI, age, sex, height and serum 25(OH)D were individually regressed on 1,25(OH)2D, height and sex were associated with 1,25(OH)2D with females exhibiting statistically significantly higher serum 1,25(OH)2D levels compared with males (P<0.001). Serum 1,25(OH)2D among our sample of children exhibiting fairly sufficient vitamin D status were higher than previous reports suggesting an adaptive mechanism to maximize calcium absorption.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25111832</pmid><doi>10.1371/journal.pone.0104825</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2014-08, Vol.9 (8), p.e104825-e104825 |
| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | 25-Hydroxyvitamin D Adolescent Adults Age Age Factors Biology and life sciences Body Height Body mass Body Mass Index Body size Calcium Calcium absorption Calcium, Dietary Child Children Children & youth Diet Female Females Girls Humans Infants Male Males Medicine and Health Sciences Metabolism Metabolites Nutrient deficiency Nutrition research Parathyroid Parathyroid hormone Parathyroid Hormone - blood Public health Regression analysis Schools Sex Sex Factors Sociodemographics Socioeconomic Factors Statistical analysis Statistical significance Students Teenagers Thailand Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin deficiency |
| title | Vitamin D status among Thai school children and the association with 1,25-Dihydroxyvitamin D and parathyroid hormone levels |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T22%3A05%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vitamin%20D%20status%20among%20Thai%20school%20children%20and%20the%20association%20with%201,25-Dihydroxyvitamin%20D%20and%20parathyroid%20hormone%20levels&rft.jtitle=PloS%20one&rft.au=Houghton,%20Lisa%20A&rft.date=2014-08-11&rft.volume=9&rft.issue=8&rft.spage=e104825&rft.epage=e104825&rft.pages=e104825-e104825&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0104825&rft_dat=%3Cproquest_plos_%3E3399487051%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1552644554&rft_id=info:pmid/25111832&rft_doaj_id=oai_doaj_org_article_f1ff89b86d1d46dcb6ad1c3b8b005b01&rfr_iscdi=true |