Beta-2 adrenergic receptor (ADRB2) gene polymorphisms and the risk of asthma: a meta-analysis of case-control studies
A number of studies have assessed the relationship between beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. However, the results are inconsistent. A meta-analysis that focused on the association between asthma and all ADRB2 polymorphisms with at least three case-control studies...
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| creator | Liang, Si-Qiao Chen, Xiao-Li Deng, Jing-Min Wei, Xuan Gong, Chen Chen, Zhang-Rong Wang, Zhi-Bo |
| description | A number of studies have assessed the relationship between beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. However, the results are inconsistent. A meta-analysis that focused on the association between asthma and all ADRB2 polymorphisms with at least three case-control studies was thus performed.
A literature search of the PubMed, Embase, Web of Science, CNKI, and Wangfang databases was conducted. Odds ratios with 95% confidence intervals were used to assess the strength of associations.
Arg16Gly, Gln27Glu, Thr164Ile, and Arg19Cys single nucleotide polymorphisms (SNPs) were identified in 46 case-control studies. The results showed that not all of the SNPs were associated with asthma in the overall population. Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179-2.609, I2 = 16.9%, studies = 2, case = 314, control = 237) in an analysis stratified by ethnicity. For the Gln27Glu polymorphism, a protective association was found in children via recessive model comparison (OR = 0.566, 95% CI = 0.417-0.769, I2 = 0.0%, studies = 11, case = 1693, control = 502) and homozygote genotype comparison (OR = 0.610, 95% CI = 0.434-0.856, I2 = 0.0%, studies = 11, case = 1693, control = 1502), and in adults via dominant model comparison (OR = 0.864, 95% CI = 0.768-0.971, I2 = 46.9%, n = 18, case = 3160, control = 3433).
None of the ADRB2 gene polymorphisms were reproducibly associated with a risk of asthma across ethnic groups in the general population. |
| doi_str_mv | 10.1371/journal.pone.0104488 |
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A literature search of the PubMed, Embase, Web of Science, CNKI, and Wangfang databases was conducted. Odds ratios with 95% confidence intervals were used to assess the strength of associations.
Arg16Gly, Gln27Glu, Thr164Ile, and Arg19Cys single nucleotide polymorphisms (SNPs) were identified in 46 case-control studies. The results showed that not all of the SNPs were associated with asthma in the overall population. Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179-2.609, I2 = 16.9%, studies = 2, case = 314, control = 237) in an analysis stratified by ethnicity. For the Gln27Glu polymorphism, a protective association was found in children via recessive model comparison (OR = 0.566, 95% CI = 0.417-0.769, I2 = 0.0%, studies = 11, case = 1693, control = 502) and homozygote genotype comparison (OR = 0.610, 95% CI = 0.434-0.856, I2 = 0.0%, studies = 11, case = 1693, control = 1502), and in adults via dominant model comparison (OR = 0.864, 95% CI = 0.768-0.971, I2 = 46.9%, n = 18, case = 3160, control = 3433).
None of the ADRB2 gene polymorphisms were reproducibly associated with a risk of asthma across ethnic groups in the general population.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0104488</identifier><identifier>PMID: 25111792</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adrenergic receptors ; Adults ; Airway management ; Asthma ; Asthma - genetics ; Biology and Life Sciences ; Case-Control Studies ; Children ; Confidence intervals ; Gene expression ; Genetic Predisposition to Disease - genetics ; Genotypes ; Hospitals ; Humans ; Medicine ; Medicine and Health Sciences ; Meta-analysis ; Minority & ethnic groups ; Mutation ; Physical Sciences ; Polymorphism ; Polymorphism, Single Nucleotide ; Population ; Receptors, Adrenergic, beta-2 - genetics ; Research and Analysis Methods ; Risk ; Signal transduction ; Single-nucleotide polymorphism ; Smooth muscle ; Studies</subject><ispartof>PloS one, 2014-08, Vol.9 (8), p.e104488-e104488</ispartof><rights>2014 Liang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Liang et al 2014 Liang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-c32951d2d29b00bda7a60d32e45c0194eaceb38d7a9a3e4165c4ce5bbd793d373</citedby><cites>FETCH-LOGICAL-c526t-c32951d2d29b00bda7a60d32e45c0194eaceb38d7a9a3e4165c4ce5bbd793d373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128804/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128804/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2930,23873,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25111792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lavoie, Pascal</contributor><creatorcontrib>Liang, Si-Qiao</creatorcontrib><creatorcontrib>Chen, Xiao-Li</creatorcontrib><creatorcontrib>Deng, Jing-Min</creatorcontrib><creatorcontrib>Wei, Xuan</creatorcontrib><creatorcontrib>Gong, Chen</creatorcontrib><creatorcontrib>Chen, Zhang-Rong</creatorcontrib><creatorcontrib>Wang, Zhi-Bo</creatorcontrib><title>Beta-2 adrenergic receptor (ADRB2) gene polymorphisms and the risk of asthma: a meta-analysis of case-control studies</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>A number of studies have assessed the relationship between beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. However, the results are inconsistent. A meta-analysis that focused on the association between asthma and all ADRB2 polymorphisms with at least three case-control studies was thus performed.
A literature search of the PubMed, Embase, Web of Science, CNKI, and Wangfang databases was conducted. Odds ratios with 95% confidence intervals were used to assess the strength of associations.
Arg16Gly, Gln27Glu, Thr164Ile, and Arg19Cys single nucleotide polymorphisms (SNPs) were identified in 46 case-control studies. The results showed that not all of the SNPs were associated with asthma in the overall population. Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179-2.609, I2 = 16.9%, studies = 2, case = 314, control = 237) in an analysis stratified by ethnicity. For the Gln27Glu polymorphism, a protective association was found in children via recessive model comparison (OR = 0.566, 95% CI = 0.417-0.769, I2 = 0.0%, studies = 11, case = 1693, control = 502) and homozygote genotype comparison (OR = 0.610, 95% CI = 0.434-0.856, I2 = 0.0%, studies = 11, case = 1693, control = 1502), and in adults via dominant model comparison (OR = 0.864, 95% CI = 0.768-0.971, I2 = 46.9%, n = 18, case = 3160, control = 3433).
None of the ADRB2 gene polymorphisms were reproducibly associated with a risk of asthma across ethnic groups in the general population.</description><subject>Adrenergic receptors</subject><subject>Adults</subject><subject>Airway management</subject><subject>Asthma</subject><subject>Asthma - genetics</subject><subject>Biology and Life Sciences</subject><subject>Case-Control Studies</subject><subject>Children</subject><subject>Confidence intervals</subject><subject>Gene expression</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotypes</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Minority & ethnic groups</subject><subject>Mutation</subject><subject>Physical Sciences</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Receptors, Adrenergic, beta-2 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Si-Qiao</au><au>Chen, Xiao-Li</au><au>Deng, Jing-Min</au><au>Wei, Xuan</au><au>Gong, Chen</au><au>Chen, Zhang-Rong</au><au>Wang, Zhi-Bo</au><au>Lavoie, Pascal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beta-2 adrenergic receptor (ADRB2) gene polymorphisms and the risk of asthma: a meta-analysis of case-control studies</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-08-11</date><risdate>2014</risdate><volume>9</volume><issue>8</issue><spage>e104488</spage><epage>e104488</epage><pages>e104488-e104488</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>A number of studies have assessed the relationship between beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. However, the results are inconsistent. A meta-analysis that focused on the association between asthma and all ADRB2 polymorphisms with at least three case-control studies was thus performed.
A literature search of the PubMed, Embase, Web of Science, CNKI, and Wangfang databases was conducted. Odds ratios with 95% confidence intervals were used to assess the strength of associations.
Arg16Gly, Gln27Glu, Thr164Ile, and Arg19Cys single nucleotide polymorphisms (SNPs) were identified in 46 case-control studies. The results showed that not all of the SNPs were associated with asthma in the overall population. Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179-2.609, I2 = 16.9%, studies = 2, case = 314, control = 237) in an analysis stratified by ethnicity. For the Gln27Glu polymorphism, a protective association was found in children via recessive model comparison (OR = 0.566, 95% CI = 0.417-0.769, I2 = 0.0%, studies = 11, case = 1693, control = 502) and homozygote genotype comparison (OR = 0.610, 95% CI = 0.434-0.856, I2 = 0.0%, studies = 11, case = 1693, control = 1502), and in adults via dominant model comparison (OR = 0.864, 95% CI = 0.768-0.971, I2 = 46.9%, n = 18, case = 3160, control = 3433).
None of the ADRB2 gene polymorphisms were reproducibly associated with a risk of asthma across ethnic groups in the general population.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25111792</pmid><doi>10.1371/journal.pone.0104488</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenergic receptors Adults Airway management Asthma Asthma - genetics Biology and Life Sciences Case-Control Studies Children Confidence intervals Gene expression Genetic Predisposition to Disease - genetics Genotypes Hospitals Humans Medicine Medicine and Health Sciences Meta-analysis Minority & ethnic groups Mutation Physical Sciences Polymorphism Polymorphism, Single Nucleotide Population Receptors, Adrenergic, beta-2 - genetics Research and Analysis Methods Risk Signal transduction Single-nucleotide polymorphism Smooth muscle Studies |
| title | Beta-2 adrenergic receptor (ADRB2) gene polymorphisms and the risk of asthma: a meta-analysis of case-control studies |
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