Enhanced cell adhesion and alignment on micro-wavy patterned surfaces

Various micropatterns have been fabricated and used to regulate cell adhesion, morphology and function. Micropatterns created by standard photolithography process are usually rectangular channels with sharp corners (microgrooves) which provide limited control over cells and are not favorable for cel...

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Veröffentlicht in:PloS one 2014-08, Vol.9 (8), p.e104502-e104502
Hauptverfasser: Hu, Jia, Hardy, Camille, Chen, Chi-Mon, Yang, Shu, Voloshin, Arkady S, Liu, Yaling
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Hardy, Camille
Chen, Chi-Mon
Yang, Shu
Voloshin, Arkady S
Liu, Yaling
description Various micropatterns have been fabricated and used to regulate cell adhesion, morphology and function. Micropatterns created by standard photolithography process are usually rectangular channels with sharp corners (microgrooves) which provide limited control over cells and are not favorable for cell-cell interaction and communication. This paper proposes a new micropattern with smooth wavy surfaces (micro-waves) to control the position and orientation of cells. To characterize cell growth and responses on the micro-patterned substrates, bovine aortic endothelial cells were seeded onto surfaces with micro-grooves and micro-waves for 24 h. As a result, the cells on the micro-wavy pattern appeared to have a lower death rate and better alignment compared to those on the micro-grooved pattern. In addition, flow-induced shear stress was applied to examine the adhesion strength of cells on the micro-wavy pattern. Results showed that cells adhered to the wavy surface displayed both improved alignment and adhesion strength compared to those on the flat surface. The combination of increased alignment, lower death rate and enhanced adhesion strength of cells on the micro-wavy patterns will offer advantages in potential applications for cell phenotype, proliferation and tissue engineering.
doi_str_mv 10.1371/journal.pone.0104502
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Micropatterns created by standard photolithography process are usually rectangular channels with sharp corners (microgrooves) which provide limited control over cells and are not favorable for cell-cell interaction and communication. This paper proposes a new micropattern with smooth wavy surfaces (micro-waves) to control the position and orientation of cells. To characterize cell growth and responses on the micro-patterned substrates, bovine aortic endothelial cells were seeded onto surfaces with micro-grooves and micro-waves for 24 h. As a result, the cells on the micro-wavy pattern appeared to have a lower death rate and better alignment compared to those on the micro-grooved pattern. In addition, flow-induced shear stress was applied to examine the adhesion strength of cells on the micro-wavy pattern. Results showed that cells adhered to the wavy surface displayed both improved alignment and adhesion strength compared to those on the flat surface. The combination of increased alignment, lower death rate and enhanced adhesion strength of cells on the micro-wavy patterns will offer advantages in potential applications for cell phenotype, proliferation and tissue engineering.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25105589</pmid><doi>10.1371/journal.pone.0104502</doi><oa>free_for_read</oa></addata></record>
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subjects Adhesion
Adhesive strength
Alignment
Animals
Aorta
Aorta - cytology
Bioengineering
Biology and Life Sciences
Cattle
Cell Adhesion
Cell adhesion & migration
Cell death
Cell interactions
Cell Line
Cell Proliferation
Cell signaling
Cytology
Endothelial cells
Endothelial Cells - cytology
Fibroblasts
Geometry
Grooves
Mechanical engineering
Mechanics
Medicine and Health Sciences
Microelectromechanical systems
Morphology
Neural networks
Phenotypes
Photolithography
Physical Sciences
Researchers
Shear stress
Studies
Substrates
Surface Properties
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds - chemistry
title Enhanced cell adhesion and alignment on micro-wavy patterned surfaces
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