Enhanced cell adhesion and alignment on micro-wavy patterned surfaces
Various micropatterns have been fabricated and used to regulate cell adhesion, morphology and function. Micropatterns created by standard photolithography process are usually rectangular channels with sharp corners (microgrooves) which provide limited control over cells and are not favorable for cel...
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description | Various micropatterns have been fabricated and used to regulate cell adhesion, morphology and function. Micropatterns created by standard photolithography process are usually rectangular channels with sharp corners (microgrooves) which provide limited control over cells and are not favorable for cell-cell interaction and communication. This paper proposes a new micropattern with smooth wavy surfaces (micro-waves) to control the position and orientation of cells. To characterize cell growth and responses on the micro-patterned substrates, bovine aortic endothelial cells were seeded onto surfaces with micro-grooves and micro-waves for 24 h. As a result, the cells on the micro-wavy pattern appeared to have a lower death rate and better alignment compared to those on the micro-grooved pattern. In addition, flow-induced shear stress was applied to examine the adhesion strength of cells on the micro-wavy pattern. Results showed that cells adhered to the wavy surface displayed both improved alignment and adhesion strength compared to those on the flat surface. The combination of increased alignment, lower death rate and enhanced adhesion strength of cells on the micro-wavy patterns will offer advantages in potential applications for cell phenotype, proliferation and tissue engineering. |
doi_str_mv | 10.1371/journal.pone.0104502 |
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Micropatterns created by standard photolithography process are usually rectangular channels with sharp corners (microgrooves) which provide limited control over cells and are not favorable for cell-cell interaction and communication. This paper proposes a new micropattern with smooth wavy surfaces (micro-waves) to control the position and orientation of cells. To characterize cell growth and responses on the micro-patterned substrates, bovine aortic endothelial cells were seeded onto surfaces with micro-grooves and micro-waves for 24 h. As a result, the cells on the micro-wavy pattern appeared to have a lower death rate and better alignment compared to those on the micro-grooved pattern. In addition, flow-induced shear stress was applied to examine the adhesion strength of cells on the micro-wavy pattern. Results showed that cells adhered to the wavy surface displayed both improved alignment and adhesion strength compared to those on the flat surface. The combination of increased alignment, lower death rate and enhanced adhesion strength of cells on the micro-wavy patterns will offer advantages in potential applications for cell phenotype, proliferation and tissue engineering.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0104502</identifier><identifier>PMID: 25105589</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adhesion ; Adhesive strength ; Alignment ; Animals ; Aorta ; Aorta - cytology ; Bioengineering ; Biology and Life Sciences ; Cattle ; Cell Adhesion ; Cell adhesion & migration ; Cell death ; Cell interactions ; Cell Line ; Cell Proliferation ; Cell signaling ; Cytology ; Endothelial cells ; Endothelial Cells - cytology ; Fibroblasts ; Geometry ; Grooves ; Mechanical engineering ; Mechanics ; Medicine and Health Sciences ; Microelectromechanical systems ; Morphology ; Neural networks ; Phenotypes ; Photolithography ; Physical Sciences ; Researchers ; Shear stress ; Studies ; Substrates ; Surface Properties ; Tissue engineering ; Tissue Engineering - methods ; Tissue Scaffolds - chemistry</subject><ispartof>PloS one, 2014-08, Vol.9 (8), p.e104502-e104502</ispartof><rights>2014 Hu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Hu et al 2014 Hu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-3c73bec9a1a1c8084b0af88f09d7fa348a08944cd39745d487d4b27cc150392d3</citedby><cites>FETCH-LOGICAL-c526t-3c73bec9a1a1c8084b0af88f09d7fa348a08944cd39745d487d4b27cc150392d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126693/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126693/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25105589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Jia</creatorcontrib><creatorcontrib>Hardy, Camille</creatorcontrib><creatorcontrib>Chen, Chi-Mon</creatorcontrib><creatorcontrib>Yang, Shu</creatorcontrib><creatorcontrib>Voloshin, Arkady S</creatorcontrib><creatorcontrib>Liu, Yaling</creatorcontrib><title>Enhanced cell adhesion and alignment on micro-wavy patterned surfaces</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Various micropatterns have been fabricated and used to regulate cell adhesion, morphology and function. Micropatterns created by standard photolithography process are usually rectangular channels with sharp corners (microgrooves) which provide limited control over cells and are not favorable for cell-cell interaction and communication. This paper proposes a new micropattern with smooth wavy surfaces (micro-waves) to control the position and orientation of cells. To characterize cell growth and responses on the micro-patterned substrates, bovine aortic endothelial cells were seeded onto surfaces with micro-grooves and micro-waves for 24 h. As a result, the cells on the micro-wavy pattern appeared to have a lower death rate and better alignment compared to those on the micro-grooved pattern. In addition, flow-induced shear stress was applied to examine the adhesion strength of cells on the micro-wavy pattern. Results showed that cells adhered to the wavy surface displayed both improved alignment and adhesion strength compared to those on the flat surface. The combination of increased alignment, lower death rate and enhanced adhesion strength of cells on the micro-wavy patterns will offer advantages in potential applications for cell phenotype, proliferation and tissue engineering.</description><subject>Adhesion</subject><subject>Adhesive strength</subject><subject>Alignment</subject><subject>Animals</subject><subject>Aorta</subject><subject>Aorta - cytology</subject><subject>Bioengineering</subject><subject>Biology and Life Sciences</subject><subject>Cattle</subject><subject>Cell Adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell death</subject><subject>Cell interactions</subject><subject>Cell Line</subject><subject>Cell Proliferation</subject><subject>Cell signaling</subject><subject>Cytology</subject><subject>Endothelial cells</subject><subject>Endothelial Cells - cytology</subject><subject>Fibroblasts</subject><subject>Geometry</subject><subject>Grooves</subject><subject>Mechanical engineering</subject><subject>Mechanics</subject><subject>Medicine and Health Sciences</subject><subject>Microelectromechanical systems</subject><subject>Morphology</subject><subject>Neural networks</subject><subject>Phenotypes</subject><subject>Photolithography</subject><subject>Physical Sciences</subject><subject>Researchers</subject><subject>Shear stress</subject><subject>Studies</subject><subject>Substrates</subject><subject>Surface Properties</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - 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cytology</topic><topic>Bioengineering</topic><topic>Biology and Life Sciences</topic><topic>Cattle</topic><topic>Cell Adhesion</topic><topic>Cell adhesion & migration</topic><topic>Cell death</topic><topic>Cell interactions</topic><topic>Cell Line</topic><topic>Cell Proliferation</topic><topic>Cell signaling</topic><topic>Cytology</topic><topic>Endothelial cells</topic><topic>Endothelial Cells - cytology</topic><topic>Fibroblasts</topic><topic>Geometry</topic><topic>Grooves</topic><topic>Mechanical engineering</topic><topic>Mechanics</topic><topic>Medicine and Health Sciences</topic><topic>Microelectromechanical systems</topic><topic>Morphology</topic><topic>Neural networks</topic><topic>Phenotypes</topic><topic>Photolithography</topic><topic>Physical Sciences</topic><topic>Researchers</topic><topic>Shear stress</topic><topic>Studies</topic><topic>Substrates</topic><topic>Surface Properties</topic><topic>Tissue engineering</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Scaffolds - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Jia</au><au>Hardy, Camille</au><au>Chen, Chi-Mon</au><au>Yang, Shu</au><au>Voloshin, Arkady S</au><au>Liu, Yaling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced cell adhesion and alignment on micro-wavy patterned surfaces</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-08-08</date><risdate>2014</risdate><volume>9</volume><issue>8</issue><spage>e104502</spage><epage>e104502</epage><pages>e104502-e104502</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Various micropatterns have been fabricated and used to regulate cell adhesion, morphology and function. Micropatterns created by standard photolithography process are usually rectangular channels with sharp corners (microgrooves) which provide limited control over cells and are not favorable for cell-cell interaction and communication. This paper proposes a new micropattern with smooth wavy surfaces (micro-waves) to control the position and orientation of cells. To characterize cell growth and responses on the micro-patterned substrates, bovine aortic endothelial cells were seeded onto surfaces with micro-grooves and micro-waves for 24 h. As a result, the cells on the micro-wavy pattern appeared to have a lower death rate and better alignment compared to those on the micro-grooved pattern. In addition, flow-induced shear stress was applied to examine the adhesion strength of cells on the micro-wavy pattern. Results showed that cells adhered to the wavy surface displayed both improved alignment and adhesion strength compared to those on the flat surface. The combination of increased alignment, lower death rate and enhanced adhesion strength of cells on the micro-wavy patterns will offer advantages in potential applications for cell phenotype, proliferation and tissue engineering.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25105589</pmid><doi>10.1371/journal.pone.0104502</doi><oa>free_for_read</oa></addata></record> |
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subjects | Adhesion Adhesive strength Alignment Animals Aorta Aorta - cytology Bioengineering Biology and Life Sciences Cattle Cell Adhesion Cell adhesion & migration Cell death Cell interactions Cell Line Cell Proliferation Cell signaling Cytology Endothelial cells Endothelial Cells - cytology Fibroblasts Geometry Grooves Mechanical engineering Mechanics Medicine and Health Sciences Microelectromechanical systems Morphology Neural networks Phenotypes Photolithography Physical Sciences Researchers Shear stress Studies Substrates Surface Properties Tissue engineering Tissue Engineering - methods Tissue Scaffolds - chemistry |
title | Enhanced cell adhesion and alignment on micro-wavy patterned surfaces |
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