Human fetal brain-derived neural stem/progenitor cells grafted into the adult epileptic brain restrain seizures in rat models of temporal lobe epilepsy

Cell transplantation has been suggested as an alternative therapy for temporal lobe epilepsy (TLE) because this can suppress spontaneous recurrent seizures in animal models. To evaluate the therapeutic potential of human neural stem/progenitor cells (huNSPCs) for treating TLE, we transplanted huNSPC...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e104092-e104092
Hauptverfasser:	Lee, Haejin, Yun, Seokhwan, Kim, Il-Sun, Lee, Il-Shin, Shin, Jeong Eun, Park, Soo Chul, Kim, Won-Joo, Park, Kook In
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analysis of Variance Animal cognition Animal models Animals Anticonvulsants Astrocytes Biology and Life Sciences Blotting, Western Brain Brain - cytology Brain - metabolism Brain research Brain stem Cell culture Cell Differentiation - physiology Cell migration Cell survival Cells (biology) Central nervous system Children & youth Chromatography, High Pressure Liquid Cognitive ability Dentate gyrus Depolarization EEG Electroencephalography Epilepsy Epilepsy, Temporal Lobe - therapy Fetus - cytology Fetuses Fibroblasts gamma-Aminobutyric Acid - metabolism Gestation Glial cell line-derived neurotrophic factor Glial Cell Line-Derived Neurotrophic Factor - metabolism Glial fibrillary acidic protein Grafting Grafts Growth factors Hippocampus Hospitals Humans Learning Medicine Medicine and Health Sciences Memory Mossy Fibers, Hippocampal - metabolism Neural stem cells Neural Stem Cells - transplantation Neurology Neuronal-glial interactions Neurons Neurosciences Oligodendrocytes Pediatrics Physicians Pilocarpine Progenitor cells Rats Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Rodents Seizing Seizures Statistics, Nonparametric Stem cells Studies Telencephalon Temporal lobe Transplantation Treatment Outcome γ-Aminobutyric acid
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