IRF7 in the Australian black flying fox, Pteropus alecto: evidence for a unique expression pattern and functional conservation

As the only flying mammal, bats harbor a number of emerging and re-emerging viruses, many of which cause severe diseases in humans and other mammals yet result in no clinical symptoms in bats. As the master regulator of the interferon (IFN)-dependent immune response, IFN regulatory factor 7 (IRF7) p...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e103875-e103875
Hauptverfasser:	Zhou, Peng, Cowled, Chris, Mansell, Ashley, Monaghan, Paul, Green, Diane, Wu, Lijun, Shi, Zhengli, Wang, Lin-Fa, Baker, Michelle L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antiviral activity Base Sequence Bats Bats (Animals) Biological response modifiers Biology and Life Sciences Chiroptera Chiroptera - genetics Chiroptera - immunology Chiroptera - metabolism Conservation Functional analysis Gene Expression Regulation - physiology Immune response Immune system Immunity Immunity, Innate - physiology Interferon Interferon regulatory factor 7 Interferon Regulatory Factor-7 - biosynthesis Interferon Regulatory Factor-7 - genetics Interferon Regulatory Factor-7 - immunology Kinases Mammals Molecular Sequence Data MyD88 protein Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - immunology Myeloid Differentiation Factor 88 - metabolism Organ Specificity - physiology Pteropus alecto Ribonucleic acid RNA siRNA Tissues Viral infections Viruses
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