Fluorosed mouse ameloblasts have increased SATB1 retention and Gαq activity

Dental fluorosis is characterized by subsurface hypomineralization and increased porosity of enamel, associated with a delay in the removal of enamel matrix proteins. To investigate the effects of fluoride on ameloblasts, A/J mice were given 50 ppm sodium fluoride in drinking water for four weeks, r...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e103994-e103994
Hauptverfasser:	Zhang, Yan, Kim, Ji-Yeon, Horst, Orapin, Nakano, Yukiko, Zhu, Li, Radlanski, Ralf J, Ho, Sunita, Den Besten, Pamela K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum fluorides Ameloblasts Ameloblasts - metabolism Ameloblasts - pathology Amelogenesis - drug effects Amelogenesis - genetics Amino acid sequence Animals Apoptosis Biology and Life Sciences Caspase Caspase 6 - genetics Caspase 6 - metabolism Caspase-6 Cellular manufacture Chromatin Computed tomography Degradation Dental enamel Dental Enamel - metabolism Dental Enamel - pathology Dental fluorosis Diacylglycerol Diglycerides Diglycerides - metabolism Drinking water Enamel Female Fluoridation Fluoride Fluorides Fluorosis Fluorosis, Dental - genetics Fluorosis, Dental - metabolism Fluorosis, Dental - pathology Gene Expression Profiling Gene Expression Regulation Genes GTP-Binding Protein alpha Subunits, Gq-G11 - genetics GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism Humans Immunohistochemistry Incisor - metabolism Incisor - pathology Incisors Kinases Male Matrix Attachment Region Binding Proteins - genetics Matrix Attachment Region Binding Proteins - metabolism Matrix Metalloproteinase 20 - genetics Matrix Metalloproteinase 20 - metabolism Maturation Mice Mineralization mRNA Oligonucleotide Array Sequence Analysis Phosphorylation Physiology Porosity Protein kinase C Protein Kinase C-alpha - genetics Protein Kinase C-alpha - metabolism Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Sodium Sodium fluoride Sodium Fluoride - pharmacology Teeth
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