A preliminary study of the relationship between promoter methylation of the ABCG1, GALNT2 and HMGCR genes and coronary heart disease

To investigate the association of ABCG1, GALNT2 and HMGCR genes promoter DNA methylation with coronary heart disease (CHD) and explore the interaction between their methylation status and the CHD patients' clinical characteristics in Han Chinese population. Methylation-specific polymerase chain...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e102265-e102265
Hauptverfasser:	Peng, Ping, Wang, Lu, Yang, Xi, Huang, Xiaoyan, Ba, Yanna, Chen, Xiaoliang, Guo, Jian, Lian, Jiangfang, Zhou, Jianqing
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCG1 gene Age Aged Aging Angiography ATP Binding Cassette Transporter, Subfamily G, Member 1 ATP-Binding Cassette Transporters - genetics Biology and life sciences Biomarkers - blood Biomarkers - metabolism Cardiovascular disease Cardiovascular diseases Cardiovascular system Cholesterol Coronary artery disease Coronary Disease - genetics Coronary Disease - metabolism Coronary vessels Deoxyribonucleic acid Diabetes mellitus DNA DNA Methylation Enzymes Epigenetics Family medical history Female Gene expression Genes Heart Heart diseases Hospitals Humans Hydroxymethylglutaryl CoA Reductases - genetics Hypertension Laboratories Lipids Male Medicine Medicine and Health Sciences Methylation Middle Aged N-Acetylgalactosaminyltransferases - genetics Patients Plasma Polymerase chain reaction Polypeptide N-acetylgalactosaminyltransferase Population (statistical) Promoter Regions, Genetic Risk Risk assessment Smoking Statistical analysis
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