Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells

Fifteen percent of tumors utilize recombination-based alternative lengthening of telomeres (ALT) to maintain telomeres. The mechanisms underlying ALT are unclear but involve several proteins involved in homologous recombination including the BLM helicase, mutated in Bloom's syndrome, and the BR...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e103819-e103819
Hauptverfasser:	Acharya, Samir, Kaul, Zeenia, Gocha, April Sandy, Martinez, Alaina R, Harris, Julia, Parvin, Jeffrey D, Groden, Joanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Bloom's syndrome Blotting, Western BRCA1 protein BRCA1 Protein - genetics BRCA1 Protein - metabolism Breast cancer Cell cycle Cell Cycle - genetics Cell Cycle - physiology Cell Line, Tumor Cells (Biology) Chromosomes Deoxyribonucleic acid DNA DNA damage DNA helicase DNA repair DNA Repair - genetics DNA Repair - physiology Fluorescent Antibody Technique Genetic recombination Genomes HeLa Cells Homologous recombination Homology Humans Immunology Immunoprecipitation Maintenance Mammals Medicine Metabolism Physiological aspects Proteins RecQ Helicases - genetics RecQ Helicases - metabolism Repair Research and Analysis Methods RNA polymerase RNA, Small Interfering Substrates Surveillance Telomerase Telomere Homeostasis - genetics Telomere Homeostasis - physiology Telomeres Tumor suppressor genes Tumors Unwinding Virology Yeast
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