Coevolutionary immune system dynamics driving pathogen speciation
We introduce and analyze a within-host dynamical model of the coevolution between rapidly mutating pathogens and the adaptive immune response. Pathogen mutation and a homeostatic constraint on lymphocytes both play a role in allowing the development of chronic infection, rather than quick pathogen c...
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| Veröffentlicht in: | PloS one 2014-07, Vol.9 (7), p.e102821-e102821 |
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| creator | Schlesinger, Kimberly J Stromberg, Sean P Carlson, Jean M |
| description | We introduce and analyze a within-host dynamical model of the coevolution between rapidly mutating pathogens and the adaptive immune response. Pathogen mutation and a homeostatic constraint on lymphocytes both play a role in allowing the development of chronic infection, rather than quick pathogen clearance. The dynamics of these chronic infections display emergent structure, including branching patterns corresponding to asexual pathogen speciation, which is fundamentally driven by the coevolutionary interaction. Over time, continued branching creates an increasingly fragile immune system, and leads to the eventual catastrophic loss of immune control. |
| doi_str_mv | 10.1371/journal.pone.0102821 |
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Pathogen mutation and a homeostatic constraint on lymphocytes both play a role in allowing the development of chronic infection, rather than quick pathogen clearance. The dynamics of these chronic infections display emergent structure, including branching patterns corresponding to asexual pathogen speciation, which is fundamentally driven by the coevolutionary interaction. Over time, continued branching creates an increasingly fragile immune system, and leads to the eventual catastrophic loss of immune control.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0102821</identifier><identifier>PMID: 25054623</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adaptation ; Adaptive immunity ; Adaptive Immunity - immunology ; Algorithms ; Analysis ; Antigens ; Biological Evolution ; Biology ; Biology and Life Sciences ; Chronic infection ; Coevolution ; Computer and Information Sciences ; Dynamic structural analysis ; Health aspects ; HIV ; Host-Pathogen Interactions - immunology ; Human immunodeficiency virus ; Humans ; Immune clearance ; Immune response ; Immune system ; Immune System - immunology ; Immune System - microbiology ; Immune System - parasitology ; Immunology ; Infection - immunology ; Infection - microbiology ; Infection - parasitology ; Infections ; Lymphocytes ; Medicine and Health Sciences ; Models, Immunological ; Mutation ; Pathogens ; Physical Sciences ; Physics ; Speciation ; System dynamics ; T-Lymphocytes - immunology ; T-Lymphocytes - microbiology ; T-Lymphocytes - parasitology ; Vaccines ; Viral infections</subject><ispartof>PloS one, 2014-07, Vol.9 (7), p.e102821-e102821</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Schlesinger et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Pathogen mutation and a homeostatic constraint on lymphocytes both play a role in allowing the development of chronic infection, rather than quick pathogen clearance. The dynamics of these chronic infections display emergent structure, including branching patterns corresponding to asexual pathogen speciation, which is fundamentally driven by the coevolutionary interaction. Over time, continued branching creates an increasingly fragile immune system, and leads to the eventual catastrophic loss of immune control.</description><subject>Adaptation</subject><subject>Adaptive immunity</subject><subject>Adaptive Immunity - immunology</subject><subject>Algorithms</subject><subject>Analysis</subject><subject>Antigens</subject><subject>Biological Evolution</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>Chronic infection</subject><subject>Coevolution</subject><subject>Computer and Information Sciences</subject><subject>Dynamic structural analysis</subject><subject>Health aspects</subject><subject>HIV</subject><subject>Host-Pathogen Interactions - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune clearance</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immune System - immunology</subject><subject>Immune System - microbiology</subject><subject>Immune System - parasitology</subject><subject>Immunology</subject><subject>Infection - immunology</subject><subject>Infection - microbiology</subject><subject>Infection - parasitology</subject><subject>Infections</subject><subject>Lymphocytes</subject><subject>Medicine and Health Sciences</subject><subject>Models, Immunological</subject><subject>Mutation</subject><subject>Pathogens</subject><subject>Physical Sciences</subject><subject>Physics</subject><subject>Speciation</subject><subject>System dynamics</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - microbiology</subject><subject>T-Lymphocytes - parasitology</subject><subject>Vaccines</subject><subject>Viral infections</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkkuL2zAUhU1p6Uyn_QelNRRKu0iqhyXLm0IIfQQGBvraClm6dhRsKbXs0Pz7yhPPEJdZFC0kpO-cqyudJHmJ0RLTHH_Y-aFzqlnuvYMlwogIgh8ll7igZMEJoo_P1hfJsxB2CDEqOH-aXBCGWMYJvUxWaw8H3wy99U51x9S27eAgDcfQQ5uao1Ot1SE1nT1YV6d71W99DS4Ne9BWjarnyZNKNQFeTPNV8vPzpx_rr4vrmy-b9ep6oXlB-gWIkivKSoxpRQwvBcsBRAa6ygtd5gozxjODcqBlCZgQIwTJQfN454ILMPQqeX3y3Tc-yKn7IDHLclEwzEgkNifCeLWT-862sSPplZW3G76rpep6qxuQjHCcGaAYAc5wqQThRtGiNFWlVVWM1T5O1YayBaPB9Z1qZqbzE2e3svYHmWEkKCuiwbvJoPO_Bwi9bG3Q0DTKgR9u7y04ZShjEX3zD_pwdxNVq9iAdZWPdfVoKlcZFpjkAqFILR-g4jAQPzJGpbJxfyZ4PxNEpoc_fa2GEOTm-7f_Z29-zdm3Z-wWVNNvwxS0MAezE6g7H0IH1f0jYyTHpN-9hhyTLqekR9mr8w-6F91Fm_4Fy-f5CA</recordid><startdate>20140723</startdate><enddate>20140723</enddate><creator>Schlesinger, Kimberly J</creator><creator>Stromberg, Sean P</creator><creator>Carlson, Jean M</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140723</creationdate><title>Coevolutionary immune system dynamics driving pathogen speciation</title><author>Schlesinger, Kimberly J ; Stromberg, Sean P ; Carlson, Jean M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-e8b6a35b113f2d6b857ee84ecf79cb7a15564d07e3bbe122d8827ec6053968ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adaptation</topic><topic>Adaptive immunity</topic><topic>Adaptive Immunity - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schlesinger, Kimberly J</au><au>Stromberg, Sean P</au><au>Carlson, Jean M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coevolutionary immune system dynamics driving pathogen speciation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-07-23</date><risdate>2014</risdate><volume>9</volume><issue>7</issue><spage>e102821</spage><epage>e102821</epage><pages>e102821-e102821</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We introduce and analyze a within-host dynamical model of the coevolution between rapidly mutating pathogens and the adaptive immune response. Pathogen mutation and a homeostatic constraint on lymphocytes both play a role in allowing the development of chronic infection, rather than quick pathogen clearance. The dynamics of these chronic infections display emergent structure, including branching patterns corresponding to asexual pathogen speciation, which is fundamentally driven by the coevolutionary interaction. Over time, continued branching creates an increasingly fragile immune system, and leads to the eventual catastrophic loss of immune control.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25054623</pmid><doi>10.1371/journal.pone.0102821</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation Adaptive immunity Adaptive Immunity - immunology Algorithms Analysis Antigens Biological Evolution Biology Biology and Life Sciences Chronic infection Coevolution Computer and Information Sciences Dynamic structural analysis Health aspects HIV Host-Pathogen Interactions - immunology Human immunodeficiency virus Humans Immune clearance Immune response Immune system Immune System - immunology Immune System - microbiology Immune System - parasitology Immunology Infection - immunology Infection - microbiology Infection - parasitology Infections Lymphocytes Medicine and Health Sciences Models, Immunological Mutation Pathogens Physical Sciences Physics Speciation System dynamics T-Lymphocytes - immunology T-Lymphocytes - microbiology T-Lymphocytes - parasitology Vaccines Viral infections |
| title | Coevolutionary immune system dynamics driving pathogen speciation |
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