Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2

MicroRNAs (miRNAs) have been reported to play a critical role in cancer invasion and metastasis. Our previous study showed that miR-375 frequently downregulated in gastric cancer suppresses cell proliferation by targeting Janus kinase 2 (JAK2). Here, we further found that the expression level of miR...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e99516-e99516
Hauptverfasser:	Xu, Yanjun, Jin, Juan, Liu, Yiman, Huang, Zhenxia, Deng, Yujie, You, Tao, Zhou, Tianhua, Si, Jianmin, Zhuo, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Biology and Life Sciences Cancer Cancer cells Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement - genetics Cell proliferation Comparative analysis Down-Regulation Ectopic expression Gastric cancer Gastroenterology Gene expression Gene Expression Regulation, Neoplastic Health aspects Hospitals Humans Janus kinase Janus kinase 2 Janus Kinase 2 - metabolism Kinases Lymphatic system Medicine Medicine and Health Sciences Metastases Metastasis MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Mortality Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Proteins Snail Family Transcription Factors Snail protein Stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - pathology Tissues Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Wound Healing - genetics
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