Visualized gene network reveals the novel target transcripts Sox2 and Pax6 of neuronal development in trans-placental exposure to bisphenol A

Bisphenol A (BPA) is a ubiquitous endocrine disrupting chemical in our daily life, and its health effect in response to prenatal exposure is still controversial. Early-life BPA exposure may impact brain development and contribute to childhood neurological disorders. The aim of the present study was...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e100576
Hauptverfasser:	Yang, Chung-Wei, Chou, Wei-Chun, Chen, Kuan-Hsueh, Cheng, An-Lin, Mao, I-Fang, Chao, How-Ran, Chuang, Chun-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Analysis Benzhydryl Compounds - toxicity Biology and Life Sciences Biomedical engineering Bisphenol A Blood Brain Cell proliferation Central Nervous System - drug effects Central Nervous System - embryology Children Cluster analysis Cord blood DNA methylation DNA microarrays Endocrine disruptors Endocrine Disruptors - toxicity Endothelial growth factors Engineering Environmental Exposure Environmental science Epigenetics Exposure Eye Proteins - genetics Eye Proteins - metabolism Female Fetuses Gene expression Gene Ontology Gene Regulatory Networks Genes Health aspects Hedgehog protein Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Hypothesis testing Insulin Insulin-like growth factors Kinases Maternal-Fetal Exchange Medicine and Health Sciences Nervous system diseases Neurological diseases Neurons Notch protein Paired Box Transcription Factors - genetics Paired Box Transcription Factors - metabolism Pax6 protein PAX6 Transcription Factor Phenols Phenols (Class of compounds) Phenols - toxicity Placenta Pregnancy Pregnant women Prenatal experience Prenatal exposure Repressor Proteins - genetics Repressor Proteins - metabolism Rodents Signaling SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Spinal cord Stem cells Transcriptome - drug effects Umbilical cord Vascular endothelial growth factor
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