Rosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo

Homologous recombination (HR) is critical for the repair of double strand breaks and broken replication forks. Although HR is mostly error free, inherent or environmental conditions that either suppress or induce HR cause genomic instability. Despite its importance in carcinogenesis, due to limitati...

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Veröffentlicht in:	PLoS genetics 2014-06, Vol.10 (6), p.e1004299
Hauptverfasser:	Sukup-Jackson, Michelle R, Kiraly, Orsolya, Kay, Jennifer E, Na, Li, Rowland, Elizabeth A, Winther, Kelly E, Chow, Danielle N, Kimoto, Takafumi, Matsuguchi, Tetsuya, Jonnalagadda, Vidya S, Maklakova, Vilena I, Singh, Vijay R, Wadduwage, Dushan N, Rajapakse, Jagath, So, Peter T C, Collier, Lara S, Engelward, Bevin P
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Aging Alliances Animals Bacterial Proteins - genetics Biology and life sciences Brain - cytology Cancer Carcinogenesis Colon - cytology Deoxyribonucleic acid Dependence Development and progression DNA DNA Breaks, Double-Stranded DNA repair DNA Repair - genetics DNA replication Flow cytometry Genetic aspects Genomic Instability - genetics Green Fluorescent Proteins - genetics Homologous Recombination - genetics Liver - cytology Luminescent Proteins - genetics Mammals Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Transgenic Mutation Pancreas - cytology Polymerase chain reaction RNA, Untranslated - genetics Rodents Studies Temozolomide
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