Ubiquitin-mediated response to microsporidia and virus infection in C. elegans

Microsporidia comprise a phylum of over 1400 species of obligate intracellular pathogens that can infect almost all animals, but little is known about the host response to these parasites. Here we use the whole-animal host C. elegans to show an in vivo role for ubiquitin-mediated response to the mic...

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Veröffentlicht in:	PLoS pathogens 2014-06, Vol.10 (6), p.e1004200-e1004200
Hauptverfasser:	Bakowski, Malina A, Desjardins, Christopher A, Smelkinson, Margery G, Dunbar, Tiffany L, Dunbar, Tiffany A, Lopez-Moyado, Isaac F, Rifkin, Scott A, Cuomo, Christina A, Troemel, Emily R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Autophagy Autophagy - genetics Autophagy - immunology Base Sequence Biology and Life Sciences Caenorhabditis elegans - immunology Caenorhabditis elegans - parasitology Caenorhabditis elegans - virology Caenorhabditis elegans Proteins - antagonists & inhibitors Caenorhabditis elegans Proteins - biosynthesis Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - immunology Caenorhabditis elegans Proteins - metabolism Cullin Proteins - biosynthesis Cullin Proteins - immunology Distribution Experiments Gene expression Genetic aspects Health aspects Host-Pathogen Interactions Infections Medical research Medicine and Health Sciences Microsporidia Microsporidia - immunology Microsporidia - pathogenicity Nematodes Research and Analysis Methods RNA Interference RNA, Small Interfering Sequence Analysis, RNA SKP Cullin F-Box Protein Ligases - antagonists & inhibitors SKP Cullin F-Box Protein Ligases - genetics SKP Cullin F-Box Protein Ligases - metabolism Transcription, Genetic - genetics Ubiquitin Ubiquitin - metabolism Ubiquitination - genetics Viral infections Worms
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