An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway

In this study, we used a systems biology approach to investigate changes in the proteome and metabolome of shrimp hemocytes infected by the invertebrate virus WSSV (white spot syndrome virus) at the viral genome replication stage (12 hpi) and the late stage (24 hpi). At 12 hpi, but not at 24 hpi, th...

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Veröffentlicht in:	PLoS pathogens 2014-06, Vol.10 (6), p.e1004196-e1004196
Hauptverfasser:	Su, Mei-An, Huang, Yun-Tzu, Chen, I-Tung, Lee, Der-Yen, Hsieh, Yun-Chieh, Li, Chun-Yuan, Ng, Tze Hann, Liang, Suh-Yuen, Lin, Shu-Yu, Huang, Shiao-Wei, Chiang, Yi-An, Yu, Hon-Tsen, Khoo, Kay-Hooi, Chang, Geen-Dong, Lo, Chu-Fang, Wang, Han-Ching
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - biosynthesis Amino Acids - metabolism Animals Biology Biology and Life Sciences Biosynthesis Cancer Citric Acid Cycle - genetics Colleges & universities Deoxyribonucleic acid Diseases DNA Energy Metabolism - genetics Gene expression Genomes Glucose metabolism Glycolysis - genetics Mass spectrometry Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Metabolites Metabolome - genetics Monomeric GTP-Binding Proteins - genetics Monosaccharides Multiprotein Complexes - antagonists & inhibitors Multiprotein Complexes - genetics Naphthyridines - pharmacology Penaeidae - metabolism Penaeidae - virology Pentose Phosphate Pathway - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Physiological aspects Proteins Proteome - genetics Proteomics Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Shrimps Sugars TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Virus Replication - genetics White spot syndrome virus 1 - genetics White spot syndrome virus 1 - metabolism
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