Perinatal exposure to low-dose methoxychlor impairs testicular development in C57BL/6 mice

Methoxychlor (MXC), an organochlorine pesticide, has adverse effects on male reproduction at toxicological doses. Humans and wild animals are exposed to MXC mostly through contaminated dietary intake. Higher concentrations of MXC have been found in human milk, raising the demand for the risk assessm...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e103016
Hauptverfasser:	Du, Xiaohong, Zhang, Hua, Liu, Yuanwu, Yu, Wanpeng, Huang, Chaobin, Li, Xiangdong
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Biology and Life Sciences Breast milk Cyclin-dependent kinase inhibitor p21 Diet Dietary intake Embryos Endocrinology Estradiol - blood Exposure Female Gene expression Genes Humans Laboratories Male Males Maternal Exposure Metabolic syndrome Metabolites Methoxychlor Methoxychlor - pharmacology Mice Mice, Inbred C57BL Molecular modelling Offspring Organic compounds Organochlorine pesticides Perinatal exposure Pesticides Polymerase chain reaction Pregnancy Prenatal Exposure Delayed Effects Reproduction Reproduction - drug effects Risk assessment Rodents Sex hormones Sperm Spermatogenesis Steroidogenesis Studies Testes Testis - drug effects Testis - growth & development Testosterone Testosterone - blood Wild animals
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