A subset of circulating blood mycobacteria-specific CD4 T cells can predict the time to Mycobacterium tuberculosis sputum culture conversion

We investigated 18 HIV-negative patients with MDR-TB for M. tuberculosis (Mtb)- and PPD-specific CD4 T cell responses and followed them over 6 months of drug therapy. Twelve of these patients were sputum culture (SC) positive and six patients were SC negative upon enrollment. Our aim was to identify...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e102178-e102178
Hauptverfasser:	Riou, Catherine, Gray, Clive M, Lugongolo, Masixole, Gwala, Thabisile, Kiravu, Agano, Deniso, Pamela, Stewart-Isherwood, Lynsey, Omar, Shaheed Vally, Grobusch, Martin P, Coetzee, Gerrit, Conradie, Francesca, Ismail, Nazir, Kaplan, Gilla, Fallows, Dorothy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens Biology and Life Sciences Biomarkers Blood Blood circulation CD4 antigen CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Cell culture Cell cycle Chemotherapy Clinical trials Cohort Studies Conversion Female Histocompatibility antigen HLA HIV - isolation & purification HIV Infections - diagnosis Humans Immunological memory Immunology Infections Infectious diseases Interleukin 2 Laboratories Lymphocytes Lymphocytes T Male Medical research Medicine Medicine and Health Sciences Memory cells Middle Aged Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - immunology Pathogenesis Patients Peripheral blood Public health Sputum Sputum - drug effects Sputum - immunology Sputum - microbiology Tuberculosis Tuberculosis - drug therapy Tuberculosis - immunology Tumor necrosis factor-α γ-Interferon
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