High dietary lipid level is associated with persistent hyperglycaemia and downregulation of muscle Akt-mTOR pathway in Senegalese sole (Solea senegalensis)

High levels of dietary lipids are incorporated in feeds for most teleost fish to promote growth and reduce nitrogen waste. However, in Senegalese sole (Solea senegalensis) previous studies revealed that increasing the level of dietary lipids above 8% negatively affect growth and nutrient utilization...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e102196
Hauptverfasser:	Borges, Pedro, Valente, Luísa M P, Véron, Vincent, Dias, Karine, Panserat, Stéphane, Médale, Françoise
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Biology and Life Sciences Blood glucose Blood Glucose - metabolism Citrate synthase Diet Dietary Carbohydrates - pharmacology Dietary Fats - pharmacology Dietary intake Down-Regulation - drug effects Dry matter Feeding Fish Fish oils Flatfishes Glucose Glucose metabolism Glucose-6-phosphatase Glycogen Hexokinase Hyperglycemia Hyperglycemia - chemically induced Hyperglycemia - metabolism Hyperglycemia - pathology Insulin Insulin resistance Kinases Levels Life Sciences Lipid metabolism Lipids Liver Metabolism Muscle Proteins - metabolism Muscles Muscles - drug effects Muscles - metabolism Muscles - pathology Nutrient content Nutrient utilization Nutrients Nutrition Oils & fats Oncorhynchus mykiss Other Phenotypes Physiological aspects Proteins Proto-Oncogene Proteins c-akt - metabolism Receptor, Insulin - metabolism Ribosomal protein S6 Ribosomal Protein S6 - metabolism Ribosomal Protein S6 Kinases, 70-kDa - metabolism Signal transduction Signal Transduction - drug effects Signaling Sole Solea senegalensis Starch TOR protein TOR Serine-Threonine Kinases - metabolism Trout
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