Decay-accelerating factor 1 deficiency exacerbates leptospiral-induced murine chronic nephritis and renal fibrosis

Leptospirosis is a global zoonosis caused by pathogenic Leptospira, which can colonize the proximal renal tubules and persist for long periods in the kidneys of infected hosts. Here, we characterized the infection of C57BL/6J wild-type and Daf1-/- mice, which have an enhanced host response, with a v...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e102860-e102860
Hauptverfasser:	Ferrer, María F, Scharrig, Emilia, Alberdi, Lucrecia, Cedola, Maia, Pretre, Gabriela, Drut, Ricardo, Song, Wen-Chao, Gomez, Ricardo M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Animals Biology and Life Sciences Bone morphogenetic proteins CD55 Antigens - metabolism Cytokines Decay-accelerating factor Developing countries Disease Extracellular matrix Fibrosis Fibrosis - metabolism Fibrosis - microbiology Galectin 3 - metabolism Galectin-3 Gene expression Health aspects House mouse Infection Infections Inflammation Inflammation - metabolism Inflammation - microbiology Interferon-gamma - metabolism Interleukin 10 Interleukin 12 Interleukin 13 Interleukin 17 Interleukin 4 Interleukins - metabolism Kidney Diseases - metabolism Kidney Diseases - microbiology Kidney Tubules, Proximal - metabolism Kidney Tubules, Proximal - microbiology Kidneys LDCs Leptospira Leptospira interrogans Leptospirosis Leptospirosis - metabolism Leptospirosis - microbiology Medicine and Health Sciences Mice Mice, Inbred C57BL Mortality Muscle proteins Muscles Nephritis Nephritis - metabolism Nephritis - mortality Pancreatitis Proximal tubules Renal tubules Rodents Smooth muscle Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Transforming growth factors Tumor necrosis factor-TNF Zoonoses γ-Interferon
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