HMGB1 promotes the development of pulmonary arterial hypertension in rats

Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary vascular resistance leading to right ventricular failure and death. Recent studies have suggested that chronic inflammatory processes are involved in the pathogenesis of PAH. However, the molecular and cellular mechanisms...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e102482-e102482
Hauptverfasser:	Sadamura-Takenaka, Yukari, Ito, Takashi, Noma, Satoshi, Oyama, Yoko, Yamada, Shingo, Kawahara, Ko-ichi, Inoue, Hiromasa, Maruyama, Ikuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animals Binding proteins Biology Biology and Life Sciences Blood pressure Bronchoalveolar Lavage Fluid - chemistry Bronchus Chemokine CCL2 - blood Chromosomal proteins Cytokines Deoxyribonucleic acid Disease Disease Models, Animal DNA DNA-binding protein DNA-Binding Proteins - metabolism Endothelin-1 - blood Epithelial cells Heart Hemodynamics High mobility group proteins HMGB1 protein HMGB1 Protein - blood HMGB1 Protein - metabolism Hypertension Hypertension, Pulmonary - physiopathology Hypertrophy, Right Ventricular - physiopathology Inflammation Inflammation - immunology Inflammation - physiopathology Inflammatory diseases Injection Interleukin-1beta - blood Localization Lungs Macrophages Male Medical prognosis Medicine Medicine and Health Sciences Monocrotaline Neutralizing Pathogenesis Protein binding Proteins Pulmonary arteries Pulmonary artery Pulmonary Artery - physiopathology Pulmonary hypertension Random Allocation Rats Rats, Sprague-Dawley Right ventricular failure Rodents Smooth muscle Survival Systolic pressure Thickening Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-TNF Tumor necrosis factor-α University graduates Vascular Resistance - physiology Veins & arteries Ventricle Ventricular Dysfunction, Right - physiopathology
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