Isolation, characterization and potential role in beta cell-endothelium cross-talk of extracellular vesicles released from human pancreatic islets

The cross-talk between beta cells and endothelium plays a key role in islet physiopathology and in the revascularization process after islet transplantation. However, the molecular mechanisms involved in this cross-talk are not fully elucidated. Extracellular vesicles (EVs) are secreted membrane nan...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e102521-e102521
Hauptverfasser:	Figliolini, Federico, Cantaluppi, Vincenzo, De Lena, Michela, Beltramo, Silvia, Romagnoli, Renato, Salizzoni, Mauro, Melzi, Raffaella, Nano, Rita, Piemonti, Lorenzo, Tetta, Ciro, Biancone, Luigi, Camussi, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inducing Agents - metabolism Apoptosis Beta cells Biological activity Biology and Life Sciences Blotting, Western Cell Communication - physiology Cell growth Cell interactions Cellular communication Conditioning Crosstalk Diabetes Endothelial cells Endothelial Cells - cytology Endothelial Cells - physiology Endothelium Extracellular vesicles Flow Cytometry Gene expression Humans Insulin Insulin secretion Insulin-Secreting Cells - physiology Islet cells Medicine and Health Sciences Membrane vesicles MicroRNA MicroRNAs - metabolism miRNA Molecular modelling Nanoparticles Nucleic acids Pancreas Pancreatic beta cells Pancreatic islet transplantation Polymerase chain reaction Proteins Receptor Cross-Talk - physiology Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA, Messenger - metabolism Rodents Secretion Stem cells Transplantation Transplants & implants Transport Vesicles - metabolism Ultracentrifugation Vascular endothelial growth factor Vesicles
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