The tumor-suppressive microRNA-135b targets c-myc in osteoscarcoma

Osteosarcoma is the most common primary tumor of the bone. It leads to many deaths because of its rapid proliferation and metastasis. Recent studies have shown that microRNAs are important gene regulators that are involved in various cancer-related processes. In this study, we found that miR-135b wa...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e102621-e102621
Hauptverfasser:	Liu, Zheng, Zhang, Guangwu, Li, Jian, Liu, Jiabang, Lv, Pengfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Analysis Base Sequence Binding Sites Biocompatibility Biology and Life Sciences Bone cancer Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Bone surgery Breast cancer c-Myc protein Cancer Cancer therapies Cell cycle Cell growth Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Child Dihydrofolate reductase Ectopic expression Ethics Female Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Humans Inhibition Luciferase Male Medicine and Health Sciences Metastases Metastasis MicroRNA MicroRNAs MicroRNAs - physiology miRNA mRNA Mutation Myc protein Neoplasm Invasiveness Orthopedics Osteosarcoma Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Osteosarcoma cells Pathogenesis Prostate cancer Protein expression Proteins Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Regulators Ribonucleic acid RNA RNA Interference Sarcoma Stem cells Stomach cancer Tissues Tumor cell lines Tumor suppressor genes Tumors
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