Wilms' tumor protein induces an epithelial-mesenchymal hybrid differentiation state in clear cell renal cell carcinoma

The Wilms' tumor transcription factor (WT1) was originally classified as a tumor suppressor, but it is now known to also be associated with cancer progression and poor prognosis in several malignancies. WT1 plays an essential role in orchestrating a developmental process known as mesenchymal-to...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e102041-e102041
Hauptverfasser:	Sampson, Valerie B, David, Justin M, Puig, Isabel, Patil, Pratima U, de Herreros, Antonio García, Thomas, George V, Rajasekaran, Ayyappan K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and life sciences Cadherins - genetics Cadherins - metabolism Cancer Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Cell adhesion & migration Cell differentiation Cell Line, Tumor Clear cell-type renal cell carcinoma Developmental biology Differentiation (biology) E-cadherin Epithelial-Mesenchymal Transition - genetics Fetge Càncer Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genotype & phenotype Humans Hypoxia Kidney cancer Kidney Neoplasms - genetics Kidney Neoplasms - pathology Kidneys Laboratories Medical research Medicine and Health Sciences Mesenchyme Metastasis Neoplasia Proteins Renal cell carcinoma Snail Family Transcription Factors Snail protein Stem cells Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Tumor suppressor genes Tumors VHL protein Von Hippel-Lindau Tumor Suppressor Protein - genetics Von Hippel-Lindau Tumor Suppressor Protein - metabolism Wilms' tumor Wnt Proteins - genetics WT1 Proteins - genetics
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