Novel missense variants of ZFPM2/FOG2 identified in conotruncal heart defect patients do not impair interaction with GATA4

Conotruncal heart defect (CTD) is a complex form of congenital heart disease and usually has a poor prognosis. ZFPM2/FOG2 encodes a transcription cofactor that interacts with GATA4 to regulate cardiac development. This regulation has been established in knockout mouse models that display a range of...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e102379-e102379
Hauptverfasser:	Zhang, Wenwen, Shen, Li, Deng, Zhantao, Ding, Yibing, Mo, Xuming, Xu, Zhengfeng, Gao, Qian, Yi, Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analysis Animal models Bioinformatics Biology and Life Sciences Cardiovascular disease Children & youth Congenital diseases Congenital heart defects Copy number Coronary artery disease Deoxyribonucleic acid DNA DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism GATA4 Transcription Factor - metabolism Genes Genetic disorders Genomes Goods and services tax Heart Heart Defects, Congenital - genetics Heart diseases Heart surgery Hospitals Humans Laboratories Medical schools Medicine Medicine and Health Sciences Molecular Sequence Data Morphogenesis Mutation Mutation, Missense Pathogenesis Patients Population studies Prognosis Proteins Sequence Homology, Amino Acid Tetralogy of Fallot Transcription Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transposition Ventricle
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