Spinal cord transection-induced allodynia in rats--behavioral, physiopathological and pharmacological characterization

In humans, spinal cord lesions induce not only major motor and neurovegetative deficits but also severe neuropathic pain which is mostly resistant to classical analgesics. Better treatments can be expected from precise characterization of underlying physiopathological mechanisms. This led us to thor...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e102027
Hauptverfasser:	M'Dahoma, Saïd, Bourgoin, Sylvie, Kayser, Valérie, Barthélémy, Sandrine, Chevarin, Caroline, Chali, Farah, Orsal, Didier, Hamon, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating transcription factor 3 Activating Transcription Factor 3 - metabolism Activation Amitriptyline Analgesics Analysis of Variance Anesthesia Animals Biology and Life Sciences Cell cycle Clonazepam Coding Cytokines Cytokines - metabolism Dorsal root ganglia Drugs Filaments Gabapentin Ganglia Ganglia, Spinal - metabolism Glial fibrillary acidic protein Hot Temperature - adverse effects Hyperalgesia - drug therapy Hyperalgesia - etiology Hyperalgesia - physiopathology Inflammation Interleukin 6 Intermediate filament proteins Isoflurane Ketamine Ketamine - therapeutic use Lesions Life Sciences Male Markers Medical innovations Medicine and Health Sciences Microglia Model testing Morphine Morphine - therapeutic use Nerve Tissue Proteins - metabolism Neuralgia Neuronal-glial interactions Neurons and Cognition Neuropathy Neurosciences Pain Pain Measurement Pain perception Pharmacology Phenols - therapeutic use Pressure Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Research and Analysis Methods Reverse Transcriptase Polymerase Chain Reaction Rodents Spinal cord injuries Spinal Cord Injuries - complications Surgery Territory Thorax Toll-like receptors Transcription factors Tumor necrosis factor-TNF
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