Radial scars and subsequent breast cancer risk: a meta-analysis
The relationship between radial scars and breast cancer is unclear, as the results of different studies are inconsistent. We aim to solve the controversy and assess the breast cancer risk of radial scars. Case-control or cohort studies about radial scars and breast cancer risk published in PubMed, W...
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| Veröffentlicht in: | PloS one 2014-07, Vol.9 (7), p.e102503-e102503 |
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| creator | Lv, Mengmeng Zhu, Xingya Zhong, Shanliang Chen, Weixian Hu, Qing Ma, Tengfei Zhang, Jun Zhang, Xiaohui Tang, Jinhai Zhao, Jianhua |
| description | The relationship between radial scars and breast cancer is unclear, as the results of different studies are inconsistent. We aim to solve the controversy and assess the breast cancer risk of radial scars.
Case-control or cohort studies about radial scars and breast cancer risk published in PubMed, Web of Science and the Cochrane Library from 2000 to 2013 were searched. Heterogeneity for the eligible data was assessed and a pooled odds ratio (OR) with 95% confidence interval (CI) was calculated.
Five observational studies involving 2521 cases and 20290 controls were included in our study. From pooled analysis, radial scars were found to have a 1.33 fold increased risk of breast cancer, but which was not significant (P = 0.138). Sample size contributed to heterogeneity. In subgroup analysis, the results pooled from studies with sample size >2000 show that presence of radial scars was associated with 1.6 times breast cancer risk compared to absence of radial scars. Radial scars increased the risk of breast cancer among women with proliferative disease without atypia, but no significant association between radial scars and carcinoma was noted among women with atypical hyperplasia.
Radial scars tend to be associated with an increased breast cancer risk. Radial scars should be considered among women with proliferative disease without atypia, while atypical hyperplasia is still the primary concern among women with both radial scars and atypical hyperplasia. |
| doi_str_mv | 10.1371/journal.pone.0102503 |
| format | Article |
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Case-control or cohort studies about radial scars and breast cancer risk published in PubMed, Web of Science and the Cochrane Library from 2000 to 2013 were searched. Heterogeneity for the eligible data was assessed and a pooled odds ratio (OR) with 95% confidence interval (CI) was calculated.
Five observational studies involving 2521 cases and 20290 controls were included in our study. From pooled analysis, radial scars were found to have a 1.33 fold increased risk of breast cancer, but which was not significant (P = 0.138). Sample size contributed to heterogeneity. In subgroup analysis, the results pooled from studies with sample size >2000 show that presence of radial scars was associated with 1.6 times breast cancer risk compared to absence of radial scars. Radial scars increased the risk of breast cancer among women with proliferative disease without atypia, but no significant association between radial scars and carcinoma was noted among women with atypical hyperplasia.
Radial scars tend to be associated with an increased breast cancer risk. Radial scars should be considered among women with proliferative disease without atypia, while atypical hyperplasia is still the primary concern among women with both radial scars and atypical hyperplasia.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0102503</identifier><identifier>PMID: 25019286</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biopsy ; Breast cancer ; Breast Diseases - pathology ; Breast Neoplasms - pathology ; Cancer ; Carcinoma - pathology ; Case-Control Studies ; Cohort analysis ; Cohort Studies ; Confidence Intervals ; Control methods ; Female ; Health aspects ; Health risk assessment ; Health risks ; Heterogeneity ; Humans ; Hyperplasia ; Hyperplasia - pathology ; Mammography ; Medicine and Health Sciences ; Meta-analysis ; Observational Studies as Topic ; Odds Ratio ; Precancerous Conditions - pathology ; Risk analysis ; Risk Factors ; Scars ; Sclerosis - pathology ; Studies ; Subgroups</subject><ispartof>PloS one, 2014-07, Vol.9 (7), p.e102503-e102503</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Lv et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Lv et al 2014 Lv et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4d12f7fe7cc982f72e0d7ac9449ac16c63daafbc44e99b89722342189d0b4b293</citedby><cites>FETCH-LOGICAL-c692t-4d12f7fe7cc982f72e0d7ac9449ac16c63daafbc44e99b89722342189d0b4b293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097058/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097058/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25019286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cheung, Annie N. Y.</contributor><creatorcontrib>Lv, Mengmeng</creatorcontrib><creatorcontrib>Zhu, Xingya</creatorcontrib><creatorcontrib>Zhong, Shanliang</creatorcontrib><creatorcontrib>Chen, Weixian</creatorcontrib><creatorcontrib>Hu, Qing</creatorcontrib><creatorcontrib>Ma, Tengfei</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Zhang, Xiaohui</creatorcontrib><creatorcontrib>Tang, Jinhai</creatorcontrib><creatorcontrib>Zhao, Jianhua</creatorcontrib><title>Radial scars and subsequent breast cancer risk: a meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The relationship between radial scars and breast cancer is unclear, as the results of different studies are inconsistent. We aim to solve the controversy and assess the breast cancer risk of radial scars.
Case-control or cohort studies about radial scars and breast cancer risk published in PubMed, Web of Science and the Cochrane Library from 2000 to 2013 were searched. Heterogeneity for the eligible data was assessed and a pooled odds ratio (OR) with 95% confidence interval (CI) was calculated.
Five observational studies involving 2521 cases and 20290 controls were included in our study. From pooled analysis, radial scars were found to have a 1.33 fold increased risk of breast cancer, but which was not significant (P = 0.138). Sample size contributed to heterogeneity. In subgroup analysis, the results pooled from studies with sample size >2000 show that presence of radial scars was associated with 1.6 times breast cancer risk compared to absence of radial scars. Radial scars increased the risk of breast cancer among women with proliferative disease without atypia, but no significant association between radial scars and carcinoma was noted among women with atypical hyperplasia.
Radial scars tend to be associated with an increased breast cancer risk. Radial scars should be considered among women with proliferative disease without atypia, while atypical hyperplasia is still the primary concern among women with both radial scars and atypical hyperplasia.</description><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast Diseases - pathology</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer</subject><subject>Carcinoma - pathology</subject><subject>Case-Control Studies</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Confidence Intervals</subject><subject>Control methods</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Hyperplasia - pathology</subject><subject>Mammography</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Observational Studies as Topic</subject><subject>Odds Ratio</subject><subject>Precancerous Conditions - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lv, Mengmeng</au><au>Zhu, Xingya</au><au>Zhong, Shanliang</au><au>Chen, Weixian</au><au>Hu, Qing</au><au>Ma, Tengfei</au><au>Zhang, Jun</au><au>Zhang, Xiaohui</au><au>Tang, Jinhai</au><au>Zhao, Jianhua</au><au>Cheung, Annie N. Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radial scars and subsequent breast cancer risk: a meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-07-14</date><risdate>2014</risdate><volume>9</volume><issue>7</issue><spage>e102503</spage><epage>e102503</epage><pages>e102503-e102503</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The relationship between radial scars and breast cancer is unclear, as the results of different studies are inconsistent. We aim to solve the controversy and assess the breast cancer risk of radial scars.
Case-control or cohort studies about radial scars and breast cancer risk published in PubMed, Web of Science and the Cochrane Library from 2000 to 2013 were searched. Heterogeneity for the eligible data was assessed and a pooled odds ratio (OR) with 95% confidence interval (CI) was calculated.
Five observational studies involving 2521 cases and 20290 controls were included in our study. From pooled analysis, radial scars were found to have a 1.33 fold increased risk of breast cancer, but which was not significant (P = 0.138). Sample size contributed to heterogeneity. In subgroup analysis, the results pooled from studies with sample size >2000 show that presence of radial scars was associated with 1.6 times breast cancer risk compared to absence of radial scars. Radial scars increased the risk of breast cancer among women with proliferative disease without atypia, but no significant association between radial scars and carcinoma was noted among women with atypical hyperplasia.
Radial scars tend to be associated with an increased breast cancer risk. Radial scars should be considered among women with proliferative disease without atypia, while atypical hyperplasia is still the primary concern among women with both radial scars and atypical hyperplasia.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25019286</pmid><doi>10.1371/journal.pone.0102503</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Biopsy Breast cancer Breast Diseases - pathology Breast Neoplasms - pathology Cancer Carcinoma - pathology Case-Control Studies Cohort analysis Cohort Studies Confidence Intervals Control methods Female Health aspects Health risk assessment Health risks Heterogeneity Humans Hyperplasia Hyperplasia - pathology Mammography Medicine and Health Sciences Meta-analysis Observational Studies as Topic Odds Ratio Precancerous Conditions - pathology Risk analysis Risk Factors Scars Sclerosis - pathology Studies Subgroups |
| title | Radial scars and subsequent breast cancer risk: a meta-analysis |
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