Investigation of a MMP-2 activity-dependent anchoring probe for nuclear imaging of cancer

Since matrix metalloproteinase-2 (MMP-2) is an important marker of tumor malignancy, we developed an original drug design strategy, MMP-2 activity dependent anchoring probes (MDAP), for use in MMP-2 activity imaging, and evaluated the usefulness of this probe in in vitro and in vivo experiments. We...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e102180-e102180
Hauptverfasser:	Temma, Takashi, Hanaoka, Hirofumi, Yonezawa, Aki, Kondo, Naoya, Sano, Kohei, Sakamoto, Takeharu, Seiki, Motoharu, Ono, Masahiro, Saji, Hideo
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Alkyl groups Anchoring Animals Biology and Life Sciences Biomarkers, Tumor - blood Blood Cancer Cell Line, Tumor Chelates Chromatography Cleavage Diagnostic Imaging Drug development Epidermal growth factor Gelatinase A Humans Imaging In vivo methods and tests Injection Injections, Intravenous Intravenous administration Investigations Malignancy Mass spectrometry Matrix metalloproteinase Matrix Metalloproteinase 2 - blood Matrix Metalloproteinase Inhibitors Medical imaging Medicine and Health Sciences Metalloproteinase Mice Molecular weight Neoplasms - blood Neoplasms - genetics Neoplasms - pathology Peptides Pharmaceutical sciences Pharmacology Physical Sciences Polyethylene glycol Polyols Probes Radioactivity Scientific imaging Solvents Substrates Tomography Tumor cells Tumors Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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