Intestinal intraepithelial lymphocyte cytometric pattern is more accurate than subepithelial deposits of anti-tissue transglutaminase IgA for the diagnosis of celiac disease in lymphocytic enteritis

An increase in CD3+TCRγδ+ and a decrease in CD3- intraepithelial lymphocytes (IEL) is a characteristic flow cytometric pattern of celiac disease (CD) with atrophy. The aim was to evaluate the usefulness of both CD IEL cytometric pattern and anti-TG2 IgA subepithelial deposit analysis (CD IF pattern)...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e101249-e101249
Hauptverfasser:	Fernández-Bañares, Fernando, Carrasco, Anna, García-Puig, Roger, Rosinach, Mercè, González, Clarisa, Alsina, Montserrat, Loras, Carme, Salas, Antonio, Viver, Josep M, Esteve, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Adolescent Adult Aged Analysis Atrophy Autoimmune diseases Biopsy CD3 antigen Celiac disease Celiac Disease - blood Celiac Disease - complications Celiac Disease - diagnosis Celiac Disease - pathology Child Child, Preschool Diagnosis Diagnostic systems Enteritis Enteritis - complications Female Females Flow Cytometry Gastroenterology Gene expression Genetics Gluten GTP-Binding Proteins - immunology Helicobacter pylori Histology Humans Immunoglobulin A Immunoglobulin A - blood Immunoglobulin A - immunology Immunoglobulins Infant Intestinal Mucosa - immunology Intestine Lymphocytes Lymphocytes - pathology Male Medical diagnosis Medicine and Health Sciences Middle Aged Patients Prospective Studies Research and Analysis Methods Sensitivity and Specificity Serologic Tests Serology Small intestine Transglutaminase 2 Transglutaminases - immunology Young Adult
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