Induction of AhR-mediated gene transcription by coffee

Aryl hydrocarbon receptor (AhR) is classically known to be activated by xenobiotics such as dioxins and polycyclic aromatic hydrocarbons (PAHs). Although it has been reported that PAHs are contained in roasted coffee beans, in general coffee beverages are not considered to be AhR activators. We test...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e102152
Hauptverfasser:	Ishikawa, Toshio, Takahashi, Satoshi, Morita, Koji, Okinaga, Hiroko, Teramoto, Tamio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Aromatic compounds Basic Helix-Loop-Helix Transcription Factors - genetics Beans Beverages Bioassays Biological assays Biology and life sciences Caco-2 Cells Cancer Cell culture Coffee Coffee (Beverage) Coffee - chemistry Coffee - classification Culture Media - chemistry Cytochrome Cytochrome P-450 Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - metabolism Cytochrome P450 Deoxyribonucleic acid Dioxins DNA Experiments Gene expression Genes Genetic aspects Hep G2 Cells Humans Internal medicine MCF-7 Cells Medical research Medicine Medicine and Health Sciences Phosphates Physical Sciences Plant Extracts - chemistry Plant Extracts - pharmacology Plasmids Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - pharmacology Polymerase chain reaction Receptors, Aryl Hydrocarbon - genetics Reporter gene RNA Transcription Transcription (Genetics) Transcription, Genetic - drug effects Western blotting Xenobiotics
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