The Ser/Thr phosphatase PP2A regulatory subunit widerborst inhibits notch signaling

Drosophila Enhancer of split M8, an effector of Notch signaling, is regulated by protein kinase CK2. The phosphatase PP2A is thought to play an opposing (inhibitory) role, but the identity of the regulatory subunit was unknown. The studies described here reveal a role for the PP2A regulatory subunit...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e101884
Hauptverfasser:	Bose, Anasua, Majot, Adam T, Bidwai, Ashok P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphibia Amphibians Animals Biology Biology and Life Sciences Birds Casein kinase II Circadian rhythm Conservation Defects Dephosphorylation Drosophila Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Drosophila Proteins - genetics Drosophila Proteins - metabolism Enhancer-of-split protein Enzymes Eye Eye - anatomy & histology Eye - pathology Genes Insects Kinases Mutation Notch protein Phosphatase Phosphatases Phosphorylation Photoreceptors Protein kinase C Protein Phosphatase 2 - metabolism Proteins Receptors, Notch - genetics Receptors, Notch - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Reptiles Signal Transduction Signaling Sleep Target recognition Wings, Animal - anatomy & histology Wings, Animal - pathology
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