Evidence that RASSF1C stimulation of lung cancer cell proliferation depends on IGFBP-5 and PIWIL1 expression levels

RASSF1C is a major isoform of the RASSF1 gene, and is emerging as an oncogene. This is in contradistinction to the RASSF1A isoform, which is an established tumor suppressor. We have previously shown that RASSF1C promotes lung cancer cell proliferation and have identified RASSF1C target genes with gr...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e101679-e101679
Hauptverfasser:	Reeves, Mark E, Firek, Matthew, Chen, Shin-Tai, Amaar, Yousef G
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antineoplastic Agents - pharmacology Apoptosis Argonaute Proteins - genetics Argonaute Proteins - metabolism beta Catenin - genetics beta Catenin - metabolism Betulinic acid Biology and Life Sciences Cancer Cell culture Cell growth Cell migration Cell Movement Cell Proliferation Cell self-renewal Drug Resistance, Neoplasm Experiments Gene Expression Gene Expression Regulation, Neoplastic Humans Hydroxamic Acids - pharmacology Insulin-Like Growth Factor Binding Protein 5 - genetics Insulin-Like Growth Factor Binding Protein 5 - metabolism Insulin-like growth factor-binding protein 5 Insulin-like growth factors Kinases Laboratories Lung cancer Lung diseases Lung Neoplasms Medical prognosis Medicine and Health Sciences Oncology Overexpression Proteins Pyrazoles - pharmacology Pyrimidines - pharmacology Signal Transduction Spheroids, Cellular Stem cells Target recognition Triterpenes - pharmacology Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumorigenesis
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