Induction of cancer stem cell properties in colon cancer cells by defined factors

Cancer stem cells (CSCs) are considered to be responsible for the dismal prognosis of cancer patients. However, little is known about the molecular mechanisms underlying the acquisition and maintenance of CSC properties in cancer cells because of their rarity in clinical samples. We herein induced C...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e101735
Hauptverfasser:	Oshima, Nobu, Yamada, Yasuhiro, Nagayama, Satoshi, Kawada, Kenji, Hasegawa, Suguru, Okabe, Hiroshi, Sakai, Yoshiharu, Aoi, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - pharmacology Biology and Life Sciences Cancer Cancer cells Cell adhesion & migration Cell culture Cell cycle Cell Line, Tumor Cell Proliferation Chemoresistance Cloning Colon Colon cancer Colonic Neoplasms - pathology Colorectal cancer Drug Resistance, Neoplasm Embryonic stem cells Flow cytometry Fluorouracil - pharmacology Gene expression Humans KLF4 protein Kruppel-Like Transcription Factors - genetics Medical research Medicine Medicine and Health Sciences Mice, Nude Molecular modelling Neoplasm Transplantation Neoplastic Stem Cells - physiology Oct-4 protein Octamer Transcription Factor-3 - genetics Pathology Phenotype Pluripotency Polymerase chain reaction Prognosis Properties (attributes) Retroviridae - genetics SOXB1 Transcription Factors - genetics Stem cells Surgery Tissues Transduction, Genetic Transplantation Tumorigenicity Tumors Xenografts Xenotransplantation
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