aldh7a1 regulates eye and limb development in zebrafish

Uveal coloboma is a potentially blinding congenital ocular malformation caused by failure of the optic fissure to close during development. Although mutations in numerous genes have been described, these account for a minority of cases, complicating molecular diagnosis and genetic counseling. Here w...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e101782
Hauptverfasser:	Babcock, Holly E, Dutta, Sunit, Alur, Ramakrishna P, Brocker, Chad, Vasiliou, Vasilis, Vitale, Susan, Abu-Asab, Mones, Brooks, Brian P
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acids Aldehyde Dehydrogenase - genetics Animals Biology and Life Sciences Cell Proliferation Coinjection Danio rerio Dehydrogenases Developmental biology DNA-Binding Proteins - genetics Embryo, Nonmammalian Embryonic Development - genetics Embryos Environmental health Extremities - embryology Eye - embryology Eye - metabolism Gene Expression Gene Expression Regulation, Developmental Gene Knockdown Techniques Genes Genetic counseling Genetic screening Genetics Genotype & phenotype Health sciences Hybridization Localization Metastasis mRNA Mutation Pediatrics Pharmaceutical sciences Phenotype Phenotypes Retina RNA Toxicology Tretinoin - pharmacology Xenopus Zebrafish Zebrafish - embryology Zebrafish - genetics Zebrafish Proteins - genetics
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