Trends and predictors of transmitted drug resistance (TDR) and clusters with TDR in a local Belgian HIV-1 epidemic

We aimed to study epidemic trends and predictors for transmitted drug resistance (TDR) in our region, its clinical impact and its association with transmission clusters. We included 778 patients from the AIDS Reference Center in Leuven (Belgium) diagnosed from 1998 to 2012. Resistance testing was pe...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e101738-e101738
Hauptverfasser:	Pineda-Peña, Andrea-Clemencia, Schrooten, Yoeri, Vinken, Lore, Ferreira, Fossie, Li, Guangdi, Trovão, Nídia Sequeira, Khouri, Ricardo, Derdelinckx, Inge, De Munter, Paul, Kücherer, Claudia, Kostrikis, Leondios G, Nielsen, Claus, Littsola, Kirsi, Wensing, Annemarie, Stanojevic, Maja, Paredes, Roger, Balotta, Claudia, Albert, Jan, Boucher, Charles, Gomez-Lopez, Arley, Van Wijngaerden, Eric, Van Ranst, Marc, Vercauteren, Jurgen, Vandamme, Anne-Mieke, Van Laethem, Kristel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult Aged AIDS AIDS (Disease) Analysis Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Bayesian analysis Belgium - epidemiology Biology Biology and Life Sciences Cladistic analysis Cluster Analysis Confidence intervals Disease transmission DNA polymerases Drug resistance Drug Resistance, Viral - genetics Epidemics Epidemiology Female Gender Genotype Health aspects HIV HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - transmission HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics Hospitals Human immunodeficiency virus Humans Immunology Infectious diseases Inflammatory diseases Internal medicine Laboratories Male Medical research Medical screening Medicine Medicine and health sciences Microbial Sensitivity Tests Middle Aged Network analysis Nucleoside reverse transcriptase inhibitors Patients Phylogenetics Phylogeny Population Pregnancy Prevalence Protease inhibitors Proteases Proteinase inhibitors Public health Public Health Surveillance Retrospective Studies Risk Factors RNA-directed DNA polymerase Sexually transmitted diseases STD Studies Surveillance Therapy Trends Virology Young Adult
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