The high diagnostic accuracy of combined test of thyroid transcription factor 1 and Napsin A to distinguish between lung adenocarcinoma and squamous cell carcinoma: a meta-analysis
Accurate classification of non-small cell lung cancer (NSCLC) using morphological features has several limitations. However, the use of thyroid transcription factor 1 (TTF-1) and Napsin A as markers for the identification of various subtypes of NSCLC has shown promise. This meta-analysis was designe...
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| creator | Li, Li Li, Xiaorong Yin, Jieyun Song, Xia Chen, Xiaochen Feng, Jiane Gao, Hongyu Liu, Li Wei, Sheng |
| description | Accurate classification of non-small cell lung cancer (NSCLC) using morphological features has several limitations. However, the use of thyroid transcription factor 1 (TTF-1) and Napsin A as markers for the identification of various subtypes of NSCLC has shown promise. This meta-analysis was designed to evaluate the diagnostic value of combined TTF-1 and Napsin A test to distinguish lung adenocarcinoma from squamous cell carcinoma.
The Medline, EMBASE and Web of Science databases were searched, along with the reference lists of relevant articles (up to May 4, 2014). Ten studies containing 1,446 subjects were identified. The sensitivity, specificity, diagnostic odds ratio (DOR) and area under the summary receiver operating characteristics curve (AUC) were calculated to estimate the combined diagnostic value of TTF-1 and Napsin A.
The pooled sensitivity and specificity were 0.76 (95% CI: 0.69-0.83) and 1.00 (95% CI: 0.92-1.00), respectively. The positive and negative likelihood ratios were 877.60 (95% CI: 8.40-91533.40) and 0.24 (95% CI: 0.18-0.32). The DOR was 3719 (95% CI: 33-414884). The AUC was 0.92 (95%CI: 0.89-0.94). The patient's location was a source of heterogeneity for sensitivity. The patient's location, the study's sample size and the threshold used to determine positive staining were consistently found to be sources of heterogeneity for specificity in subgroup analyses and meta-regression.
The combined test of TTF-1 and Napsin A presents a promising alternative method, useful to distinguish between lung adenocarcinoma and squamous cell carcinoma. |
| doi_str_mv | 10.1371/journal.pone.0100837 |
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The Medline, EMBASE and Web of Science databases were searched, along with the reference lists of relevant articles (up to May 4, 2014). Ten studies containing 1,446 subjects were identified. The sensitivity, specificity, diagnostic odds ratio (DOR) and area under the summary receiver operating characteristics curve (AUC) were calculated to estimate the combined diagnostic value of TTF-1 and Napsin A.
The pooled sensitivity and specificity were 0.76 (95% CI: 0.69-0.83) and 1.00 (95% CI: 0.92-1.00), respectively. The positive and negative likelihood ratios were 877.60 (95% CI: 8.40-91533.40) and 0.24 (95% CI: 0.18-0.32). The DOR was 3719 (95% CI: 33-414884). The AUC was 0.92 (95%CI: 0.89-0.94). The patient's location was a source of heterogeneity for sensitivity. The patient's location, the study's sample size and the threshold used to determine positive staining were consistently found to be sources of heterogeneity for specificity in subgroup analyses and meta-regression.
The combined test of TTF-1 and Napsin A presents a promising alternative method, useful to distinguish between lung adenocarcinoma and squamous cell carcinoma.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0100837</identifier><identifier>PMID: 25003505</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accuracy ; Adenocarcinoma ; Adenocarcinoma - diagnosis ; Adenocarcinoma - metabolism ; Adenocarcinoma of Lung ; Analysis ; Aspartic Acid Endopeptidases - metabolism ; Biology and Life Sciences ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - metabolism ; Diagnosis ; Diagnosis, Differential ; Diagnostic systems ; Epidemiology ; Epidermal growth factor ; Heterogeneity ; Humans ; Immunohistochemistry - methods ; Lung cancer ; Lung diseases ; Lung Neoplasms - diagnosis ; Lung Neoplasms - metabolism ; Medical diagnosis ; Medical research ; Medicine and Health Sciences ; Meta-analysis ; Mutation ; Non-small cell lung cancer ; Non-small cell lung carcinoma ; Nuclear Proteins - metabolism ; Online databases ; Public health ; Regression analysis ; Science ; Sensitivity ; Sensitivity and Specificity ; Squamous cell carcinoma ; Studies ; Subgroups ; Thyroid ; Thyroid gland ; Thyroid Nuclear Factor 1 ; Thyroid transcription factor 1 ; Transcription factors ; Transcription Factors - metabolism ; Tumors</subject><ispartof>PloS one, 2014-07, Vol.9 (7), p.e100837-e100837</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Li et al 2014 Li et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-7a05b41f68ada7ab4ac17ed341bc24629e4fcdcf978cf0e44071b730c1f215e33</citedby><cites>FETCH-LOGICAL-c692t-7a05b41f68ada7ab4ac17ed341bc24629e4fcdcf978cf0e44071b730c1f215e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086931/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086931/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25003505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Minna, John D.</contributor><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Li, Xiaorong</creatorcontrib><creatorcontrib>Yin, Jieyun</creatorcontrib><creatorcontrib>Song, Xia</creatorcontrib><creatorcontrib>Chen, Xiaochen</creatorcontrib><creatorcontrib>Feng, Jiane</creatorcontrib><creatorcontrib>Gao, Hongyu</creatorcontrib><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Wei, Sheng</creatorcontrib><title>The high diagnostic accuracy of combined test of thyroid transcription factor 1 and Napsin A to distinguish between lung adenocarcinoma and squamous cell carcinoma: a meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Accurate classification of non-small cell lung cancer (NSCLC) using morphological features has several limitations. However, the use of thyroid transcription factor 1 (TTF-1) and Napsin A as markers for the identification of various subtypes of NSCLC has shown promise. This meta-analysis was designed to evaluate the diagnostic value of combined TTF-1 and Napsin A test to distinguish lung adenocarcinoma from squamous cell carcinoma.
The Medline, EMBASE and Web of Science databases were searched, along with the reference lists of relevant articles (up to May 4, 2014). Ten studies containing 1,446 subjects were identified. The sensitivity, specificity, diagnostic odds ratio (DOR) and area under the summary receiver operating characteristics curve (AUC) were calculated to estimate the combined diagnostic value of TTF-1 and Napsin A.
The pooled sensitivity and specificity were 0.76 (95% CI: 0.69-0.83) and 1.00 (95% CI: 0.92-1.00), respectively. The positive and negative likelihood ratios were 877.60 (95% CI: 8.40-91533.40) and 0.24 (95% CI: 0.18-0.32). The DOR was 3719 (95% CI: 33-414884). The AUC was 0.92 (95%CI: 0.89-0.94). The patient's location was a source of heterogeneity for sensitivity. The patient's location, the study's sample size and the threshold used to determine positive staining were consistently found to be sources of heterogeneity for specificity in subgroup analyses and meta-regression.
The combined test of TTF-1 and Napsin A presents a promising alternative method, useful to distinguish between lung adenocarcinoma and squamous cell carcinoma.</description><subject>Accuracy</subject><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma of Lung</subject><subject>Analysis</subject><subject>Aspartic Acid Endopeptidases - metabolism</subject><subject>Biology and Life Sciences</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Diagnostic systems</subject><subject>Epidemiology</subject><subject>Epidermal growth factor</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - metabolism</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Mutation</subject><subject>Non-small cell lung cancer</subject><subject>Non-small cell lung carcinoma</subject><subject>Nuclear Proteins - metabolism</subject><subject>Online databases</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Science</subject><subject>Sensitivity</subject><subject>Sensitivity and Specificity</subject><subject>Squamous cell carcinoma</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Nuclear Factor 1</subject><subject>Thyroid transcription factor 1</subject><subject>Transcription factors</subject><subject>Transcription Factors - metabolism</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MWOnVMvkKqKw0oVlaBwa02cSeIqsbe2A-x78YA43W3VRb1Avogz_ua357cnSZ4zumS8YO8u7eQMDMu1NbikjNKSFw-SQ1bxdJGnlD-8Mz9Innh_SWnGyzx_nBykGaU8o9lh8ueiR9LrrieNhs5YH7QioNTkQG2IbYmyY60NNiSgD3Mg9Btndfx3YLxyeh20NaQFFawjjIBpyBdYe23ICQk2ykZJ003a96TG8AvRkGEyHYEGjVXglDZ2hOs8fzXBaCdPFA4DuV07JkBGDLCAWO_Ga_80edTC4PHZ7nuUfP_44eL08-Ls_NPq9ORsofIqDYsCaFYL1uYlNFBALUCxAhsuWK1SkacVilY1qq2KUrUUhaAFqwtOFWtTliHnR8nLre56sF7uDPeSZYJHrKrySKy2RGPhUq6dHsFtpAUtrwPWdRJctHRAGe3GrCyzjFeFqIsaalbWWamwSas2bzBqvd_tNtUjNgpNtHjYE91fMbqXnf0pBS3zirMo8GYn4OzVFK9LjtrPVoLB6Op8bsHTNL8-96t_0Pur21EdxAK0aW3cV82i8kSwMuei4FmklvdQcTQ4ahVfZ6tjfC_h7V5CZAL-Dh1M3svVt6__z57_2Gdf32F7hCH03g7T_ED9Pii2oHLWe4ftrcmMyrm5btyQc3PJXXPFtBd3L-g26aab-F-YmyKv</recordid><startdate>20140708</startdate><enddate>20140708</enddate><creator>Li, Li</creator><creator>Li, Xiaorong</creator><creator>Yin, Jieyun</creator><creator>Song, Xia</creator><creator>Chen, Xiaochen</creator><creator>Feng, Jiane</creator><creator>Gao, Hongyu</creator><creator>Liu, Li</creator><creator>Wei, Sheng</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140708</creationdate><title>The high diagnostic accuracy of combined test of thyroid transcription factor 1 and Napsin A to distinguish between lung adenocarcinoma and squamous cell carcinoma: a meta-analysis</title><author>Li, Li ; Li, Xiaorong ; Yin, Jieyun ; Song, Xia ; Chen, Xiaochen ; Feng, Jiane ; Gao, Hongyu ; Liu, Li ; Wei, Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-7a05b41f68ada7ab4ac17ed341bc24629e4fcdcf978cf0e44071b730c1f215e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Accuracy</topic><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma of Lung</topic><topic>Analysis</topic><topic>Aspartic Acid Endopeptidases - metabolism</topic><topic>Biology and Life Sciences</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Diagnostic systems</topic><topic>Epidemiology</topic><topic>Epidermal growth factor</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - metabolism</topic><topic>Medical diagnosis</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>Mutation</topic><topic>Non-small cell lung cancer</topic><topic>Non-small cell lung carcinoma</topic><topic>Nuclear Proteins - metabolism</topic><topic>Online databases</topic><topic>Public health</topic><topic>Regression analysis</topic><topic>Science</topic><topic>Sensitivity</topic><topic>Sensitivity and Specificity</topic><topic>Squamous cell carcinoma</topic><topic>Studies</topic><topic>Subgroups</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid Nuclear Factor 1</topic><topic>Thyroid transcription factor 1</topic><topic>Transcription factors</topic><topic>Transcription Factors - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Li</au><au>Li, Xiaorong</au><au>Yin, Jieyun</au><au>Song, Xia</au><au>Chen, Xiaochen</au><au>Feng, Jiane</au><au>Gao, Hongyu</au><au>Liu, Li</au><au>Wei, Sheng</au><au>Minna, John D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The high diagnostic accuracy of combined test of thyroid transcription factor 1 and Napsin A to distinguish between lung adenocarcinoma and squamous cell carcinoma: a meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-07-08</date><risdate>2014</risdate><volume>9</volume><issue>7</issue><spage>e100837</spage><epage>e100837</epage><pages>e100837-e100837</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Accurate classification of non-small cell lung cancer (NSCLC) using morphological features has several limitations. However, the use of thyroid transcription factor 1 (TTF-1) and Napsin A as markers for the identification of various subtypes of NSCLC has shown promise. This meta-analysis was designed to evaluate the diagnostic value of combined TTF-1 and Napsin A test to distinguish lung adenocarcinoma from squamous cell carcinoma.
The Medline, EMBASE and Web of Science databases were searched, along with the reference lists of relevant articles (up to May 4, 2014). Ten studies containing 1,446 subjects were identified. The sensitivity, specificity, diagnostic odds ratio (DOR) and area under the summary receiver operating characteristics curve (AUC) were calculated to estimate the combined diagnostic value of TTF-1 and Napsin A.
The pooled sensitivity and specificity were 0.76 (95% CI: 0.69-0.83) and 1.00 (95% CI: 0.92-1.00), respectively. The positive and negative likelihood ratios were 877.60 (95% CI: 8.40-91533.40) and 0.24 (95% CI: 0.18-0.32). The DOR was 3719 (95% CI: 33-414884). The AUC was 0.92 (95%CI: 0.89-0.94). The patient's location was a source of heterogeneity for sensitivity. The patient's location, the study's sample size and the threshold used to determine positive staining were consistently found to be sources of heterogeneity for specificity in subgroup analyses and meta-regression.
The combined test of TTF-1 and Napsin A presents a promising alternative method, useful to distinguish between lung adenocarcinoma and squamous cell carcinoma.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25003505</pmid><doi>10.1371/journal.pone.0100837</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-07, Vol.9 (7), p.e100837-e100837 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1543730996 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Accuracy Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - metabolism Adenocarcinoma of Lung Analysis Aspartic Acid Endopeptidases - metabolism Biology and Life Sciences Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - metabolism Diagnosis Diagnosis, Differential Diagnostic systems Epidemiology Epidermal growth factor Heterogeneity Humans Immunohistochemistry - methods Lung cancer Lung diseases Lung Neoplasms - diagnosis Lung Neoplasms - metabolism Medical diagnosis Medical research Medicine and Health Sciences Meta-analysis Mutation Non-small cell lung cancer Non-small cell lung carcinoma Nuclear Proteins - metabolism Online databases Public health Regression analysis Science Sensitivity Sensitivity and Specificity Squamous cell carcinoma Studies Subgroups Thyroid Thyroid gland Thyroid Nuclear Factor 1 Thyroid transcription factor 1 Transcription factors Transcription Factors - metabolism Tumors |
| title | The high diagnostic accuracy of combined test of thyroid transcription factor 1 and Napsin A to distinguish between lung adenocarcinoma and squamous cell carcinoma: a meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T12%3A10%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20high%20diagnostic%20accuracy%20of%20combined%20test%20of%20thyroid%20transcription%20factor%201%20and%20Napsin%20A%20to%20distinguish%20between%20lung%20adenocarcinoma%20and%20squamous%20cell%20carcinoma:%20a%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Li,%20Li&rft.date=2014-07-08&rft.volume=9&rft.issue=7&rft.spage=e100837&rft.epage=e100837&rft.pages=e100837-e100837&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0100837&rft_dat=%3Cgale_plos_%3EA418634735%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1543730996&rft_id=info:pmid/25003505&rft_galeid=A418634735&rft_doaj_id=oai_doaj_org_article_505e588553974b7bab18b58ced29f6de&rfr_iscdi=true |