Endothelial nitric oxide synthase and superoxide mediate hemodynamic initiation of intracranial aneurysms

Hemodynamic insults at arterial bifurcations are believed to play a critical role in initiating intracranial aneurysms. Recent studies in a rabbit model indicate that aneurysmal damage initiates under specific wall shear stress conditions when smooth muscle cells (SMCs) become pro-inflammatory and p...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e101721
Hauptverfasser:	Liaw, Nicholas, Fox, Jennifer M Dolan, Siddiqui, Adnan H, Meng, Hui, Kolega, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Aerospace engineering Analysis Aneurysm Animals Bifurcations Biology and Life Sciences Blood pressure Carotid artery Cyclic N-Oxides - administration & dosage Damage Disease Models, Animal Endothelium Female Gelatinase A Gelatinase B Hemodynamics Immunofluorescence Immunohistochemistry Inflammation Intracranial Aneurysm - metabolism Intracranial Aneurysm - pathology Isoforms Matrix metalloproteinases Matrix Metalloproteinases, Membrane-Associated - metabolism Muscle proteins Muscles Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology NG-Nitroarginine Methyl Ester - administration & dosage Nitric oxide Nitric Oxide Synthase - metabolism Nitric-oxide synthase Oxygen Peroxynitrite Phenotypes Protein Synthesis Inhibitors - administration & dosage Rabbits Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Shear stress Smooth muscle Spin Labels Superoxide Superoxides Superoxides - metabolism Tempol Veins & arteries Wall shear stresses
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