Association of angiotensin II type 1 receptor (A1166C) gene polymorphism and its increased expression in essential hypertension: a case-control study
Hypertension is one of the major cardiovascular diseases. It affects nearly 1.56 billion people worldwide. The present study is about a particular genetic polymorphism (A1166C), gene expression and protein expression of the angiotensin II type I receptor (AT1R) (SNP ID: rs5186) and its association w...
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| Veröffentlicht in: | PloS one 2014-07, Vol.9 (7), p.e101502-e101502 |
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| creator | Chandra, Sudhir Narang, Rajiv Sreenivas, Vishnubhatla Bhatia, Jagriti Saluja, Daman Srivastava, Kamna |
| description | Hypertension is one of the major cardiovascular diseases. It affects nearly 1.56 billion people worldwide. The present study is about a particular genetic polymorphism (A1166C), gene expression and protein expression of the angiotensin II type I receptor (AT1R) (SNP ID: rs5186) and its association with essential hypertension in a Northern Indian population.
We analyzed the A1166C polymorphism and expression of AT1R gene in 250 patients with essential hypertension and 250 normal healthy controls.
A significant association was found in the AT1R genotypes (AC+CC) with essential hypertension (χ2 = 22.48, p = 0.0001). Individuals with CC genotypes were at 2.4 times higher odds (p = 0.0001) to develop essential hypertension than individuals with AC and AA genotypes. The statistically significant intergenotypic variation in the systolic blood pressure was found higher in the patients with CC (169.4±36.3 mmHg) as compared to that of AA (143.5±28.1 mmHg) and AC (153.9±30.5 mmHg) genotypes (p = 0.0001). We found a significant difference in the average delta-CT value (p = 0.0001) wherein an upregulated gene expression (approximately 16 fold) was observed in case of patients as compared to controls. Furthermore, higher expression of AT1R gene was observed in patients with CC genotype than with AC and AA genotypes. A significant difference (p = 0.0001) in the protein expression of angiotensin II Type 1 receptor was also observed in the plasma of patients (1.49±0.27) as compared to controls (0.80±0.24).
Our findings suggest that C allele of A1166C polymorphism in the angiotensin II type 1 receptor gene is associated with essential hypertension and its upregulation could play an important role in essential hypertension. |
| doi_str_mv | 10.1371/journal.pone.0101502 |
| format | Article |
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We analyzed the A1166C polymorphism and expression of AT1R gene in 250 patients with essential hypertension and 250 normal healthy controls.
A significant association was found in the AT1R genotypes (AC+CC) with essential hypertension (χ2 = 22.48, p = 0.0001). Individuals with CC genotypes were at 2.4 times higher odds (p = 0.0001) to develop essential hypertension than individuals with AC and AA genotypes. The statistically significant intergenotypic variation in the systolic blood pressure was found higher in the patients with CC (169.4±36.3 mmHg) as compared to that of AA (143.5±28.1 mmHg) and AC (153.9±30.5 mmHg) genotypes (p = 0.0001). We found a significant difference in the average delta-CT value (p = 0.0001) wherein an upregulated gene expression (approximately 16 fold) was observed in case of patients as compared to controls. Furthermore, higher expression of AT1R gene was observed in patients with CC genotype than with AC and AA genotypes. A significant difference (p = 0.0001) in the protein expression of angiotensin II Type 1 receptor was also observed in the plasma of patients (1.49±0.27) as compared to controls (0.80±0.24).
Our findings suggest that C allele of A1166C polymorphism in the angiotensin II type 1 receptor gene is associated with essential hypertension and its upregulation could play an important role in essential hypertension.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0101502</identifier><identifier>PMID: 24992666</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Alleles ; Analysis ; Angiotensin ; Angiotensin II ; Angiotensins ; Biology and Life Sciences ; Blood Pressure ; Cardiovascular disease ; Cardiovascular diseases ; Case-Control Studies ; Essential Hypertension ; Female ; Gene expression ; Gene Frequency ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genotype ; Genotypes ; Health risk assessment ; Heart diseases ; Humans ; Hypertension ; Hypertension - genetics ; Hypertension - pathology ; Male ; Medicine and Health Sciences ; Middle Aged ; Patients ; Polymorphism ; Polymorphism, Single Nucleotide ; Receptor, Angiotensin, Type 1 - genetics ; Receptor, Angiotensin, Type 1 - metabolism ; Rodents ; Single-nucleotide polymorphism ; Statistical analysis ; Studies ; Up-Regulation</subject><ispartof>PloS one, 2014-07, Vol.9 (7), p.e101502-e101502</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Chandra et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Chandra et al 2014 Chandra et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-e3ee3b58267f8f1e561e4ab3a3b3e374672bb6e0ef28c5eabca203a65f2082653</citedby><cites>FETCH-LOGICAL-c659t-e3ee3b58267f8f1e561e4ab3a3b3e374672bb6e0ef28c5eabca203a65f2082653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081645/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081645/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23853,27911,27912,53778,53780,79355,79356</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24992666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mittal, Balraj</contributor><creatorcontrib>Chandra, Sudhir</creatorcontrib><creatorcontrib>Narang, Rajiv</creatorcontrib><creatorcontrib>Sreenivas, Vishnubhatla</creatorcontrib><creatorcontrib>Bhatia, Jagriti</creatorcontrib><creatorcontrib>Saluja, Daman</creatorcontrib><creatorcontrib>Srivastava, Kamna</creatorcontrib><title>Association of angiotensin II type 1 receptor (A1166C) gene polymorphism and its increased expression in essential hypertension: a case-control study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Hypertension is one of the major cardiovascular diseases. It affects nearly 1.56 billion people worldwide. The present study is about a particular genetic polymorphism (A1166C), gene expression and protein expression of the angiotensin II type I receptor (AT1R) (SNP ID: rs5186) and its association with essential hypertension in a Northern Indian population.
We analyzed the A1166C polymorphism and expression of AT1R gene in 250 patients with essential hypertension and 250 normal healthy controls.
A significant association was found in the AT1R genotypes (AC+CC) with essential hypertension (χ2 = 22.48, p = 0.0001). Individuals with CC genotypes were at 2.4 times higher odds (p = 0.0001) to develop essential hypertension than individuals with AC and AA genotypes. The statistically significant intergenotypic variation in the systolic blood pressure was found higher in the patients with CC (169.4±36.3 mmHg) as compared to that of AA (143.5±28.1 mmHg) and AC (153.9±30.5 mmHg) genotypes (p = 0.0001). We found a significant difference in the average delta-CT value (p = 0.0001) wherein an upregulated gene expression (approximately 16 fold) was observed in case of patients as compared to controls. Furthermore, higher expression of AT1R gene was observed in patients with CC genotype than with AC and AA genotypes. A significant difference (p = 0.0001) in the protein expression of angiotensin II Type 1 receptor was also observed in the plasma of patients (1.49±0.27) as compared to controls (0.80±0.24).
Our findings suggest that C allele of A1166C polymorphism in the angiotensin II type 1 receptor gene is associated with essential hypertension and its upregulation could play an important role in essential hypertension.</description><subject>Adult</subject><subject>Alleles</subject><subject>Analysis</subject><subject>Angiotensin</subject><subject>Angiotensin II</subject><subject>Angiotensins</subject><subject>Biology and Life Sciences</subject><subject>Blood Pressure</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Case-Control Studies</subject><subject>Essential Hypertension</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - 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genetics</topic><topic>Hypertension - pathology</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptor, Angiotensin, Type 1 - genetics</topic><topic>Receptor, Angiotensin, Type 1 - metabolism</topic><topic>Rodents</topic><topic>Single-nucleotide polymorphism</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chandra, Sudhir</creatorcontrib><creatorcontrib>Narang, Rajiv</creatorcontrib><creatorcontrib>Sreenivas, Vishnubhatla</creatorcontrib><creatorcontrib>Bhatia, Jagriti</creatorcontrib><creatorcontrib>Saluja, Daman</creatorcontrib><creatorcontrib>Srivastava, Kamna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chandra, Sudhir</au><au>Narang, Rajiv</au><au>Sreenivas, Vishnubhatla</au><au>Bhatia, Jagriti</au><au>Saluja, Daman</au><au>Srivastava, Kamna</au><au>Mittal, Balraj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of angiotensin II type 1 receptor (A1166C) gene polymorphism and its increased expression in essential hypertension: a case-control study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-07-03</date><risdate>2014</risdate><volume>9</volume><issue>7</issue><spage>e101502</spage><epage>e101502</epage><pages>e101502-e101502</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Hypertension is one of the major cardiovascular diseases. It affects nearly 1.56 billion people worldwide. The present study is about a particular genetic polymorphism (A1166C), gene expression and protein expression of the angiotensin II type I receptor (AT1R) (SNP ID: rs5186) and its association with essential hypertension in a Northern Indian population.
We analyzed the A1166C polymorphism and expression of AT1R gene in 250 patients with essential hypertension and 250 normal healthy controls.
A significant association was found in the AT1R genotypes (AC+CC) with essential hypertension (χ2 = 22.48, p = 0.0001). Individuals with CC genotypes were at 2.4 times higher odds (p = 0.0001) to develop essential hypertension than individuals with AC and AA genotypes. The statistically significant intergenotypic variation in the systolic blood pressure was found higher in the patients with CC (169.4±36.3 mmHg) as compared to that of AA (143.5±28.1 mmHg) and AC (153.9±30.5 mmHg) genotypes (p = 0.0001). We found a significant difference in the average delta-CT value (p = 0.0001) wherein an upregulated gene expression (approximately 16 fold) was observed in case of patients as compared to controls. Furthermore, higher expression of AT1R gene was observed in patients with CC genotype than with AC and AA genotypes. A significant difference (p = 0.0001) in the protein expression of angiotensin II Type 1 receptor was also observed in the plasma of patients (1.49±0.27) as compared to controls (0.80±0.24).
Our findings suggest that C allele of A1166C polymorphism in the angiotensin II type 1 receptor gene is associated with essential hypertension and its upregulation could play an important role in essential hypertension.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24992666</pmid><doi>10.1371/journal.pone.0101502</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Alleles Analysis Angiotensin Angiotensin II Angiotensins Biology and Life Sciences Blood Pressure Cardiovascular disease Cardiovascular diseases Case-Control Studies Essential Hypertension Female Gene expression Gene Frequency Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genotype Genotypes Health risk assessment Heart diseases Humans Hypertension Hypertension - genetics Hypertension - pathology Male Medicine and Health Sciences Middle Aged Patients Polymorphism Polymorphism, Single Nucleotide Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism Rodents Single-nucleotide polymorphism Statistical analysis Studies Up-Regulation |
| title | Association of angiotensin II type 1 receptor (A1166C) gene polymorphism and its increased expression in essential hypertension: a case-control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T23%3A52%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20angiotensin%20II%20type%201%20receptor%20(A1166C)%20gene%20polymorphism%20and%20its%20increased%20expression%20in%20essential%20hypertension:%20a%20case-control%20study&rft.jtitle=PloS%20one&rft.au=Chandra,%20Sudhir&rft.date=2014-07-03&rft.volume=9&rft.issue=7&rft.spage=e101502&rft.epage=e101502&rft.pages=e101502-e101502&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0101502&rft_dat=%3Cgale_plos_%3EA416968772%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1542870367&rft_id=info:pmid/24992666&rft_galeid=A416968772&rft_doaj_id=oai_doaj_org_article_a2d05846ac5440f5b5e1df530580c5f3&rfr_iscdi=true |