An unstable Th epitope of P. falciparum fosters central memory T cells and anti-CS antibody responses

Malaria is transmitted by Plasmodium-infected anopheles mosquitoes. Widespread resistance of mosquitoes to insecticides and resistance of parasites to drugs highlight the urgent need for malaria vaccines. The most advanced malaria vaccines target sporozoites, the infective form of the parasite. A ma...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e100639-e100639
Hauptverfasser:	Parra-López, Carlos A, Bernal-Estévez, David, Yin, Liusong, Vargas, Luis Eduardo, Pulido-Calixto, Carolina, Salazar, Luz Mary, Calvo-Calle, J Mauricio, Stern, Lawrence J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibodies Antibodies, Protozoan - immunology Antibody response Antigenic determinants Antigens Aquatic insects B cells Biochemistry Biology and Life Sciences C-Terminus CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell adhesion & migration Circumsporozoite protein Culicidae Drug resistance Editing Epitopes Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Female Genetic engineering Haplotypes Histocompatibility antigen HLA HLA-DR4 Antigen - genetics HLA-DR4 Antigen - immunology Humans Immunization Immunogenicity Immunoglobulins Immunologic Memory Immunological memory Immunology Infectivity Insecticide resistance Insecticides Lymphocytes Lymphocytes T Major histocompatibility complex Malaria Malaria vaccines Malaria Vaccines - genetics Malaria Vaccines - immunology Male Medicine Medicine and Health Sciences Memory cells Mice Mice, Transgenic Mosquitoes Parasite resistance Parasites Peptides Plasmodium falciparum Plasmodium falciparum - immunology Primates Protein Stability Proteins Protozoan Proteins - genetics Protozoan Proteins - immunology Rodentia Rodents Sporozoites T cell receptors T cells Transgenic mice Tyrosine Vaccines Vector-borne diseases γ-Interferon
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